188023-72-5Relevant academic research and scientific papers
The Role of Molecular Oxygen in Clavulanic Acid Biosynthesis: Evidence for a Bacterial Oxidative Deamination
Townsend, Craig A.,Krol, Walter J.
, p. 1234 - 1236 (1988)
Growth of cultures of Streptomyces clavuligerus (ATCC 27064) in an 18O2-containing atmosphere resulted in efficient and equal incorporations of molecular oxygen into the oxazolidine ring and the allylic hydroxy group of clavulanic acid.
Probable role of clavaminic acid as the terminal intermediate in the common pathway to clavulanic acid and the antipodal clavam metabolites
Egan, Laura A.,Busby, Robert W.,Iwata-Reuyl, Dirk,Townsend, Craig A.
, p. 2348 - 2355 (2007/10/03)
Emerging chemical and genetic evidence suggests that separate biochemical solutions have evolved to synthesize the four known classes of β-lactam antibiotics. One of these classes contains clavulanic acid (1) and a family of structurally related but antip
