134312-06-4

Upstream product

• 5098-14-6 2-aminomalononitrile p-toluenesulfonate 
• 2284-20-0 4-Methoxyphenyl isothiocyanate 

Downstream Products

• 1393591-49-5 N₂-(4-methoxyphenyl)-5,6,7,8-tetrahydro[1,3]thiazolo[5,4-b]quinoline-2,9-diamine 
• 1393591-48-4 N₂-(4-methoxyphenyl)-6,7-dihydro-5H-cyclopenta[b][1,3]thiazolo[4,5-e]pyridine-2,8-diamine 
• 134312-12-2 7-amino-2-<(4-methoxyphenyl)amino>thiazolo<5,4-d>pyrimidine 

Relevant academic research and scientific papers

Synthesis of new selenophene and thiazole analogues of the Tacrine series

New 2-aminoselenophene-3-carbonitriles and 5-amino-1,3-thiazole-4- carbonitriles were made and reacted with cycloalkanones to give tetrahydroselenolo[2,3-b ]quinolines, cycloalkene-fused selenolo[3,2-e] pyridines, [1,3]thiazolo[5,4-b]quinolines, thiazolo[

Reaction of Aminopropanedinitrile 4-Methylbenzenesulfonate (Aminomalononitrile p-Toluenesulfonate (Tosylate)) with Isothiocyanates

Aminopropanedinitrile 4-methylbenzenesulfonate (ammoniopropanedinitrile or aminomalononitrile p-toluenesulfonate (tosylate)) reacts with alkyl and aryl isothiocyanates in 1-methyl-2-pyrrolidinone (NMP) to give 5-amino-2-(alkylamino)-4-cyanothiazoles and 5-amino-2-(arylamino)-4-cyanothiazoles (2,5-diaminothiazole-4-carbonitriles), respectively, which react with amidines or ortho esters to afford 7-amino-2-(alkylamino)thiazolopyrimidines and 7-amino-2-amino-2-(arylamino)thiazolopyrimidines.