134312-12-2Relevant academic research and scientific papers
Reaction of Aminopropanedinitrile 4-Methylbenzenesulfonate (Aminomalononitrile p-Toluenesulfonate (Tosylate)) with Isothiocyanates
Freeman, Fillmore,Kim, Darrick S. H. L.
, p. 4645 - 4648 (2007/10/02)
Aminopropanedinitrile 4-methylbenzenesulfonate (ammoniopropanedinitrile or aminomalononitrile p-toluenesulfonate (tosylate)) reacts with alkyl and aryl isothiocyanates in 1-methyl-2-pyrrolidinone (NMP) to give 5-amino-2-(alkylamino)-4-cyanothiazoles and 5-amino-2-(arylamino)-4-cyanothiazoles (2,5-diaminothiazole-4-carbonitriles), respectively, which react with amidines or ortho esters to afford 7-amino-2-(alkylamino)thiazolopyrimidines and 7-amino-2-amino-2-(arylamino)thiazolopyrimidines.
