134334-93-3Relevant academic research and scientific papers
Design and Synthesis of Potent, Selective, and Orally Active Fluorine-Containing Renin Inhibitors
Doherty, Annette M.,Sircar, Ila,Kornberg, Brian E.,Quin, John,Winters, Thomas R.,et al.
, p. 2 - 14 (2007/10/02)
A series of primate renin inhibitors containing difluorocarbinol and difluoroketone groups at the P1 - P1' position have been synthesized and studied both in vitro and in vivo.In vitro, the compounds were evaluated as inhibitors of m
Renin Inhibitors Containing Esters at the P2-Position. Oral Activity in a Derivative of Methyl Aminomalonate
Repine, Joseph,Himmelsbach, Richard J.,Hodges, John C.,Kaltenbronn, James S.,Sircar, Ila,et al.
, p. 1935 - 1943 (2007/10/02)
A series of renin inhibitors containing ester side chains at the P2 subsite are potent inhibitors of primate renin.Derivatives containing the diol isostere (ACDMH) at P1-P'1 were the most potent inhibitors.Moderate selectivity for re
