1343422-06-9

Upstream product

• 39629-86-2 5-oxo-1-phenyl-3-pyrrolidinecarboxylic acid 
• 62-53-3 aniline 
• 97-65-4 2-methylenesuccinic acid 
• 873562-52-8 C₁₄H₁₃N₃O₂ 
• 1343422-04-7 methyl 3-oxo-3-(5-oxo-1-phenylpyrrolidin-3-yl)propanoate 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 1343422-17-2 C₁₈H₂₂N₄O₂ 
• 1343422-21-8 C₂₀H₂₆N₄O₂ 
• 1343422-24-1 6{2; 2} 
• 1343422-25-2 C₂₂H₂₂N₄O₂ 

Relevant academic research and scientific papers

Parallel synthesis of 2-substituted 6-(5-Oxo-1-phenylpyrrolidin-3-yl) pyrimidine-5-carboxamides

A library of 24 6-(5-oxo-1-phenylpyrrolidin-3-yl)pyrimidine-5-carboxamides 10{1,2; 1-12} was prepared by a parallel solution-phase approach. The synthesis comprises a five-step transformation of itaconic acid (11) into 1-methyl and 1-phenyl substituted 6-(5-oxo-1-phenylpyrrolidin-3-yl)pyrimidine-5-carboxylic acids 17{1,2} followed by parallel amidation of 17{1,2} with a series of 12 aliphatic amines 18{1-12} to afford the corresponding carboxamides 10 in good overall yields and in 80-100% purity.

Parallel synthesis of 1-substituted 5-(5-oxopyrrolidin-3-yl)-1 H -pyrazole-4-carboxamides

A parallel solution-phase synthesis of 5-(5-oxo-1-phenylpyrrolidin-3-yl)- 1H-pyrazole-4-carboxamide derivatives as conformationally constrained pyrazole analogues of histamine starting from itaconic acid was developed. The synthetic method comprises a five-step preparation of 1-substituted 5-(5-oxo-1- phenylpyrrolidin-3-yl)-1H-pyrazole-4-carboxylic acids followed by parallel amidation with various primary and secondary amines to give a library of 24 histamine analogues in good overall yields and in very high purities. The method is general and substrate-independent. All the amidations proceed smoothly and no major difference in reactivity is observed with respect to the structures of the reactants. Georg Thieme Verlag Stuttgart, New York.