1343422-17-2

Upstream product

• 107-10-8 propylamine 
• 1343422-04-7 methyl 3-oxo-3-(5-oxo-1-phenylpyrrolidin-3-yl)propanoate 
• 1343422-06-9 methyl 3-(dimethylamino)-2-(5-oxo-1-phenylpyrrolidine-3-carbonyl)acrylate 
• 1343422-09-2 methyl 1-methyl-5-(5-oxo-1-phenylpyrrolidin-3-yl)-1H-pyrazole-4-carboxylate 
• 1343422-12-7 1-methyl-5-(5-oxo-1-phenylpyrrolidin-3-yl)-1H-pyrazole-4-carboxylic acid 
• 873562-52-8 C₁₄H₁₃N₃O₂ 
• 97-65-4 2-methylenesuccinic acid 
• 39629-86-2 5-oxo-1-phenyl-3-pyrrolidinecarboxylic acid 
• 62-53-3 aniline 

Relevant academic research and scientific papers

Parallel synthesis of 1-substituted 5-(5-oxopyrrolidin-3-yl)-1 H -pyrazole-4-carboxamides

A parallel solution-phase synthesis of 5-(5-oxo-1-phenylpyrrolidin-3-yl)- 1H-pyrazole-4-carboxamide derivatives as conformationally constrained pyrazole analogues of histamine starting from itaconic acid was developed. The synthetic method comprises a five-step preparation of 1-substituted 5-(5-oxo-1- phenylpyrrolidin-3-yl)-1H-pyrazole-4-carboxylic acids followed by parallel amidation with various primary and secondary amines to give a library of 24 histamine analogues in good overall yields and in very high purities. The method is general and substrate-independent. All the amidations proceed smoothly and no major difference in reactivity is observed with respect to the structures of the reactants. Georg Thieme Verlag Stuttgart, New York.