1343493-72-0Relevant academic research and scientific papers
Synthesis, pharmacophore modeling and in vitro activity of 10,11-dihydrodibenzo[b,f]oxepine-4-carboxamide derivatives as novel and potent antagonists of the prostaglandin EP4 receptor
Stasi, Luigi Piero,Bhimani, Kanji,Borriello, Manuela,Canciani, Luca,Caselli, Gianfranco,Colace, Fabrizio,Ferioli, Cristian,Kaswala, Mehul,Mennuni, Laura,Piepoli, Tiziana,Pucci, Sabrina,Salvi, Matteo,Shirsath, Vikas,Zanelli, Tiziano,Zerbi, Silvia
scheme or table, p. 6336 - 6340 (2011/12/02)
The construction of a EP4 antagonists pharmacophore model and the discovery of a highly potent oxepinic series of EP4 antagonists is discussed. Compound 1a exhibits an excellent selectivity profile toward EP2 receptor subtype and low cytochrome P450 inhibition potential.
