1343493-82-2Relevant academic research and scientific papers
Synthesis, pharmacophore modeling and in vitro activity of 10,11-dihydrodibenzo[b,f]oxepine-4-carboxamide derivatives as novel and potent antagonists of the prostaglandin EP4 receptor
Stasi, Luigi Piero,Bhimani, Kanji,Borriello, Manuela,Canciani, Luca,Caselli, Gianfranco,Colace, Fabrizio,Ferioli, Cristian,Kaswala, Mehul,Mennuni, Laura,Piepoli, Tiziana,Pucci, Sabrina,Salvi, Matteo,Shirsath, Vikas,Zanelli, Tiziano,Zerbi, Silvia
, p. 6336 - 6340 (2011/12/02)
The construction of a EP4 antagonists pharmacophore model and the discovery of a highly potent oxepinic series of EP4 antagonists is discussed. Compound 1a exhibits an excellent selectivity profile toward EP2 receptor subtype and low cytochrome P450 inhibition potential.
