1343498-72-5 Usage
Uses
Used in Oncology:
N-Desmethyl Regorafenib is used as an anticancer agent for the treatment and prevention of various types of cancer. It modulates several oncological signaling pathways, including JAK/STAT, RAS/RAF/mTOR, TGF-β1/TGF-β1R, VEGF/VEGFR, and CXCL12/CXCR4 axes, exerting inhibitory effects on tumor growth and progression. Additionally, it demonstrates synergistic anticancer effects when combined with conventional chemotherapeutic drugs, enhancing chemo-sensitivity and efficacy in resistant cases.
Check Digit Verification of cas no
The CAS Registry Mumber 1343498-72-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,4,3,4,9 and 8 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1343498-72:
(9*1)+(8*3)+(7*4)+(6*3)+(5*4)+(4*9)+(3*8)+(2*7)+(1*2)=175
175 % 10 = 5
So 1343498-72-5 is a valid CAS Registry Number.
1343498-72-5Relevant academic research and scientific papers
Preparation method of multi-target anti-tumor drug
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Paragraph 0026; 0028; 0030, (2021/01/25)
The invention relates to a preparation method of a multi-target anti-tumor drug. The method comprises the following steps: 1, nitrogen protection: by using a williamson ether synthesis method, using 4-amino-3-fluorophenol and 4-chlorine-2-pyridine carboxa
Synthesis method of metafenib
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Paragraph 0011, (2017/07/20)
The invention relates to a synthesis method of an anti-cancer active compound-metafenib. The chemical name of metafenib is 4-4{4-[3-(4-chloro-3-trifluoromethylphenyl)urea]-3-flrophenoxy}pyridine-2-methnamide (the compound 1). Metafenib is prepared by taki
