757251-54-0

Basic information

• Product Name: 4-(4-AMino-3-fluorophenoxy)-pyridine-2-carboxylic acid aMide
• Synonyms: 4-(4-AMino-3-fluorophenoxy)-pyridine-2-carboxylic acid aMide;2-PyridinecarboxaMide, 4-(4-aMino-3-fluorophenoxy)-;4-(4-Amino-3-fluorophenoxy)picolinamide;4-(4-Amino-3-fluorophenoxy)pyridine-2-carboxamide;4-(4-amino-3-fluorophenoxy)-2-Pyridinecarboxamide
• CAS NO: 757251-54-0
• Molecular Formula: C₁₂H₁₀FN₃O₂
• Molecular Weight: 247.2251032
• EINECS: -0
• Mol File: 757251-54-0.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Density: 1.385
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility: Acetontrile (Slightly, Heated), Chloroform (Slightly, Heated)
• CAS DataBase Reference: 4-(4-AMino-3-fluorophenoxy)-pyridine-2-carboxylic acid aMide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-AMino-3-fluorophenoxy)-pyridine-2-carboxylic acid aMide(757251-54-0)
• EPA Substance Registry System: 4-(4-AMino-3-fluorophenoxy)-pyridine-2-carboxylic acid aMide(757251-54-0)

Safety Data

• Hazardous Substances Data: 757251-54-0(Hazardous Substances Data)

Usage

Uses

4-?(4-?Amino-?3-?fluorophenoxy)?pyridine-?2-?carboxamide is a reagent used in the synthesis of heterocyclic urea derivatives as kinase inhibitors in the treatment of myeloproliferative and other diseases.

Upstream product

• 99586-65-9 4-chloropicolinamide 
• 399-95-1 4-amino-3-fluorophenol 

Downstream Products

• 928038-30-6 4-(3-Fluoro-4-{[1-(4-fluorophenylcarbamoyl)cyclopropanecarbonyl] amino }phenoxy)pyridine-2-carboxamide 
• 868735-77-7 4-(3-fluoro-4-pivalamidophenoxy)picolinamide 
• 1009816-09-4 1-[4-(2-carbamoylpyridin-4-yloxy)-2-fluorophenylcarbamoyl]cyclopropanecarboxylic acid benzyl ester 
• 1020172-30-8 1-(4-(2-carbamoylpyridin-4-yloxy)-2-fluorophenyl)-3-(3-ethyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl)urea 
• 1343498-72-5 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-2-pyridinecarboxamide 
• 928038-32-8 N-{4-[(2-Aminopyridin-4-yl)oxy]-2-fluorophenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide monohydrochloride 
• 928038-31-7 N-{4-[(2-Aminopyridin-4-yl)oxy]-2-fluorophenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 
• 1181341-13-8 4-[3-fluoro-4-(2,2,2-trichloroacetylamino)phenoxy]pyridine-2-carboxylic acid amide 
• 1181341-03-6 [4-(2-carbamoylpyridin-4-yloxy)-2-fluorophenyl]carbamic acid t-butyl ester 
• 1181341-10-5 4-[3-fluoro-4-(2,2,2-trifluoroacetylamino)phenoxy]pyridine-2-carboxylic acid amide 

Relevant articles and documents

Preparation method of multi-target anti-tumor drug

The invention relates to a preparation method of a multi-target anti-tumor drug. The method comprises the following steps: 1, nitrogen protection: by using a williamson ether synthesis method, using 4-amino-3-fluorophenol and 4-chlorine-2-pyridine carboxa

Synthesis method of metafenib

The invention relates to a synthesis method of an anti-cancer active compound-metafenib. The chemical name of metafenib is 4-4{4-[3-(4-chloro-3-trifluoromethylphenyl)urea]-3-flrophenoxy}pyridine-2-methnamide (the compound 1). Metafenib is prepared by taki

PYRIDINE OR PYRIMIDINE DERIVATIVE HAVING EXCELLENT CELL GROWTH INHIBITION EFFECT AND EXCELLENT ANTI-TUMOR EFFECT ON CELL STRAIN HAVING AMPLIFICATION OF HGFR GENE

A pyridine or pyrimidine derivative represented by the formula (I) has an excellent HGFR inhibitory activity and exhibits strong cell proliferation inhibitory effect and anti-tumor effect against cancer cell lines with amplified HGFR gene. wherein R1 represents a 3- to 10-membered non-aromatic heterocyclic group or the like; R2 and R3 represent hydrogen; R4, R5, R6, and R7 may be the same or different and each represents hydrogen, halogen, C1-6 alkyl or the like; R8 represents hydrogen or the like; R9 represents a 3- to 10-membered non-aromatic heterocyclic group or the like; n represents an integer of 1 or 2; X represents -CH=, nitrogen.