1344029-97-5Relevant academic research and scientific papers
A Novel Synthesis of N -Sulfonylformamidines from N Sulfonyl sulfonamides
Jeong, Yuri,Ban, Jaeyoung,Lim, Minkyung,Rhee, Hakjune
, p. 1867 - 1874 (2018)
N -Sulfonylformamidines were synthesized from N -sulfonylsulfonamides by reacting with p -toluenesulfonyl chloride (TsCl) and N, N - disubstituted formamides. In this reaction, it was expected that mixing TsCl with the N, N -disubstituted formamide would generate an iminium salt (Vilsmeier reagent). The reaction avoids the use of metal catalysts and hazardous reagents, and the desired N -sulfonylformamidines were obtained in 60% to quantitative yields.
Preparation method of sulfonyl amidine with 2-Picolylamine and DMF-DMA as amine sources
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Paragraph 0074; 0076, (2020/09/09)
The invention discloses a preparation method of sulfonyl amidine with 2-Picolylamine and DMF-DMA as amine sources. The method comprises the following steps: reacting sulfonyl chloride with 2-Picolylamine to obtain an intermediate product; and then reacting the intermediate product with DMF-DMA in the presence of a catalyst at a temperature of 60-100 DEG C, then performing cooling to room temperature, extracting the reaction solution with ethyl acetate, performing layering, drying and then concentrating to obtain a target product sulfonyl amidine. According to the method disclosed by the invention, the reaction of secondary sulfonamide and DMF-DMA is realized, and the synthesis path of sulfonyl amidine is expanded. The synthetic reaction is simple in operation, mild in condition and convenient in post-treatment, and the obtained intermediate product and the product are high in purity and yield.
Otherwise inert reaction of sulfonamides/carboxamides with formamides via proton transfer-enhanced reactivity
Niu, Zaihai,Lin, Shaoxia,Dong, Zhiyong,Sun, Hao,Liang, Fushun,Zhang, Jingping
, p. 2460 - 2465 (2013/06/04)
NBS-mediated addition-elimination reaction of sulfonamides/carboxamides and formamides afforded N-sulfonylamidines and N-formylarylamides, respectively, depending on the different mechanism of elimination. Hydrogen bond-induced proton transfer leads to en
Direct condensation of sulfonamide and formamide: NaI-catalyzed synthesis of N-sulfonyl formamidine using TBHP as oxidant
Chen, Shulin,Xu, Yuan,Wan, Xiaobing
supporting information; experimental part, p. 6152 - 6155 (2012/01/03)
A new N-sulfonyl formamidine synthesis was developed via NaI-catalyzed direct condensation of sulfonamide and formamide. The green methodology is featured by high atom economy, easily available starting materials, the lack of need for a transition-metal c
