134403-91-1

Basic information

• Product Name: methyl 4-(2-hydroxyethyl)-3-nitrobenzoate
• Synonyms: methyl 4-(2-hydroxyethyl)-3-nitrobenzoate
• CAS NO: 134403-91-1
• Molecular Weight: 225.201
• Mol File: 134403-91-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: methyl 4-(2-hydroxyethyl)-3-nitrobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-(2-hydroxyethyl)-3-nitrobenzoate(134403-91-1)
• EPA Substance Registry System: methyl 4-(2-hydroxyethyl)-3-nitrobenzoate(134403-91-1)

Safety Data

• Hazardous Substances Data: 134403-91-1(Hazardous Substances Data)

Upstream product

• 69395-13-7 4-(2-hydroxyethyl)benzonitrile 
• 50-00-0 formaldehyd 
• 7356-11-8 4-methyl-3-nitro-benzoic acid methyl ester 
• 75867-41-3 4-trimethylsilanylethynyl-benzoic acid methyl ester 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 67-56-1 methanol 
• 134403-89-7 4-(2-acetyloxyethyl)-3-nitrobenzonitrile 

Downstream Products

• 134403-97-7 2-(4-(methoxycarbonyl)-2-nitrophenyl)ethyl chloroformate 
• 142599-82-4 4-[2-((2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-3-yloxycarbonyloxy)-ethyl]-3-nitro-benzoic acid methyl ester 
• 142599-81-3 4-[2-((2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{4-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yloxycarbonyloxy)-ethyl]-3-nitro-benzoic acid methyl ester 
• 142599-84-6 4-[2-((2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{4-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yloxycarbonyloxy)-ethyl]-3-nitro-benzoic acid 

Relevant articles and documents

Chemoselective Cleavage of Si-C(sp3) Bonds in Unactivated Tetraalkylsilanes Using Iodine Tris(trifluoroacetate)

Organosilanes are synthetically useful reagents and precursors in organic chemistry. However, the typical inertness of unactivated Si-C(sp3) bonds under conventional reaction conditions has hampered the application of simple tetraalkylsilanes in organic synthesis. Herein we report the chemoselective cleavage of Si-C(sp3) bonds of unactivated tetraalkylsilanes using iodine tris(trifluoroacetate). The reaction proceeds smoothly under mild conditions (-50 °C to room temperature) and tolerates various polar functional groups, thus enabling subsequent Tamao-Fleming oxidation to provide the corresponding alcohols. NMR experiments and density functional theory calculations on the reaction indicate that the transfer of alkyl groups from Si to the I(III) center and the formation of the Si-O bond proceed concertedly to afford an alkyl-λ3-iodane and silyl trifluoroacetate. The developed method enables the use of unactivated tetraalkylsilanes as highly stable synthetic precursors.

A synthetic procedure for the preparation of oligonucleotides without using ammonia and its application for the synthesis of oligonucleotides containing O-4-alkyl thymidines

The preparation of 5'-O-dimethoxytrityl (DMT) and p-nitrophenylethyl (NPEOC, NPE) protected nucleosides linked to 4-(2-hydroxyethyl)-3-nitrobenzoic acid derivatives is described. These products attached to controlled-pore glass supports and together with