134403-92-2

Upstream product

• 75-44-5 phosgene 
• 134020-63-6 2,4,5-Trichlorophenyl 4'-(2-hydroxyethyl)-3'-nitrobenzoate 
• 69395-14-8 4-(2-hydroxyethyl)-3-nitrobenzonitrile 
• 95-95-4 2,4,5-trichlorophenol 
• 134403-89-7 4-(2-acetyloxyethyl)-3-nitrobenzonitrile 
• 134403-90-0 4-(2-hydroxyethyl)-3-nitrobenzoic acid 
• 69395-13-7 4-(2-hydroxyethyl)benzonitrile 

Downstream Products

• 134403-95-5 4-(2,3'-(5'-O-4,4'-dimethoxytrityl-thymidyl)carbonyloxyethyl)-3-nitrobenzoate 2,4,5-trichlorophenyl ester 

Relevant academic research and scientific papers

A synthetic procedure for the preparation of oligonucleotides without using ammonia and its application for the synthesis of oligonucleotides containing O-4-alkyl thymidines

The preparation of 5'-O-dimethoxytrityl (DMT) and p-nitrophenylethyl (NPEOC, NPE) protected nucleosides linked to 4-(2-hydroxyethyl)-3-nitrobenzoic acid derivatives is described. These products attached to controlled-pore glass supports and together with

NPE-resin, a new approach to the solid-phase synthesis of protected peptides and oligonucleotides I: Synthesis of the supports and their application to oligonucleotide synthesis

The preparation of polymeric supports containing a base labile 2-(2-nitrophenyl) ethyl linkage and the attachment of protected nucleosides is described together with their application to oligonucleotide synthesis.