1344109-55-2

Basic information

• Product Name: phenyl(1-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)pyrrol-3-yl)methanone
• Synonyms: phenyl(1-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)pyrrol-3-yl)methanone
• CAS NO: 1344109-55-2
• Molecular Weight: 303.125
• Mol File: 1344109-55-2.mol

Chemical Properties

• CAS DataBase Reference: phenyl(1-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)pyrrol-3-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: phenyl(1-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)pyrrol-3-yl)methanone(1344109-55-2)
• EPA Substance Registry System: phenyl(1-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)pyrrol-3-yl)methanone(1344109-55-2)

Safety Data

• Hazardous Substances Data: 1344109-55-2(Hazardous Substances Data)

Upstream product

• 1344109-43-8 2-bromo-4-(pyrrol-1-yl)benzoic acid methyl ester 
• 1344109-47-2 2-bromo-4-(pyrrol-1-yl)benzyl alcohol 
• 1344109-52-9 6-(pyrrol-1-yl)-1,3-dihydro-1-hydroxy-2,1-benzoxaborole 
• 98-88-4 benzoyl chloride 
• 7745-93-9 2-bromo-4-nitrotoluene 
• 16426-64-5 2-bromo-4-nitrobenzoic acid 
• 100959-22-6 methyl 2-bromo-4-nitrobenzoate 
• 98545-64-3 methyl-2-bromo-4-aminobenzoate 
• 856794-72-4 2-bromo-4-nitrobenzoyl chloride 

Downstream Products

• 1615685-32-9 6-(3-benzylpyrrol-1-yl)-1,3-dihydro-1-hydroxy-2,1-benzoxaborole 

Relevant articles and documents

Novel pyrrolobenzoxaboroles: Design, synthesis, and biological evaluation against Trypanosoma brucei

Human African trypanosomiasis is a fatal parasitic infection caused by the protozoan Trypanosoma brucei. The development of novel antitrypanosomal agents is urgently needed. Here we report the synthesis and structure-activity relationship of a new class of benzoxaboroles as antitrypanosomal agents. These compounds showed antiparasitic IC50 values ranging from 4.02 to 0.03 μg/mL and satisfactory cytotoxicity profile. Three of the lead compounds were demonstrated to cure the parasitic infection in a murine acute infection model. The structure-activity relationship of the pyrrolobenzoxaboroles are also discussed.

Synthesis of a novel pyrrolo-benzoxaborole scaffold and its derivatization via Friedel-Crafts reaction catalyzed by anhydrous stannic chloride

A novel pyrrolo-benzoxaborole, 6-(pyrrol-1-yl)-1,3-dihydro-1-hydroxy-2,1- benzoxaborole, was synthesized with 27% overall yield over six steps from 2-bromo-1-methyl-4-nitrobenzene as starting material. Its derivatization was achieved via Friedel-Crafts re