1344112-08-8Relevant academic research and scientific papers
Enhanced antitumor potential induced by chloroacetate-loaded benzophenones acting as fused tubulin-pyruvate dehydrogenase kinase 1 (PDHK1) ligands
Dubois, Jo?lle,Farce, Amaury,Floquet, Emilie,Ghinet, Alina,Rigo, Beno?t,Thuru, Xavier
, (2020/02/11)
The majority of cancers detected every year are treated with anti-cancer compounds. Unfortunately, many tumors become resistant to antineoplastic drugs. One option is to use cocktails of compounds acting on different targets to try to overcome the resista
Eaton's reagent-mediated domino π-cationic arylations of aromatic carboxylic acids to iasi-red polymethoxylated polycyclic aromatic hydrocarbons: Products with unprecedented biological activities as tubulin polymerization inhibitors
Ghinet, Alina,Gautret, Philippe,Hijfte, Nathalie Van,Lede, Bertrand,Henichart, Jean-Pierre,Bicu, Elena,Darbost, Ulrich,Rigo, Benoit,Daich, Adam
supporting information, p. 10117 - 10130 (2014/08/18)
A rapid domino π-cationic arylation of aromatic carboxylic acids, mediated by Eaton's reagent, has been developed for the synthesis of Iasi-red polymethoxylated polycyclic aromatic hydrocarbons (PAHs). This route is currently the easiest method to obtain
Synthesis and biological evaluation of phenstatin metabolites
Ghinet, Alina,Rigo, Beno?t,Hénichart, Jean-Pierre,Le Broc-Ryckewaert, Delphine,Pommery, Jean,Pommery, Nicole,Thuru, Xavier,Quesnel, Bruno,Gautret, Philippe
experimental part, p. 6042 - 6054 (2011/11/29)
Previous investigations on the incubation of phenstatin with rat and human microsomal fractions revealed the formation of nine main metabolites. The structures of eight of these metabolites have been now confirmed by synthesis and their biological properties have been reported. Eaton's reagent was utilized as a convenient condensing agent, allowing, among others, a simple multigram scale preparation of phenstatin. Synthesized metabolites and related compounds were evaluated for their antiproliferative activity in the NCI-60 cancer cell line panel, and for their effect on microtubule assembly. Metabolite 23 (2′-methoxyphenstatin) exhibited the most potent in vitro cytotoxic activity: inhibition of the growth of K-562, NCI-H322M, NCI-H522, KM12, M14, MDA-MB-435, NCI/ADR-RES, and HS 578T cell lines with GI50 values 50 = 3.2 μM vs 15.0 μM) and induced G2/M arrest in murine leukemia DA1-3b cells. The identification of this active metabolite led to the design and synthesis of analogs with potent in vitro cytotoxicity and inhibition of microtubule assembly.
