134420-70-5

Basic information

• Product Name: Benzenepentanoic acid, b-amino-, ethyl ester
• CAS NO: 134420-70-5
• Molecular Formula: C13H19NO2
• Molecular Weight: 221.299
• Mol File: 134420-70-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzenepentanoic acid, b-amino-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepentanoic acid, b-amino-, ethyl ester(134420-70-5)
• EPA Substance Registry System: Benzenepentanoic acid, b-amino-, ethyl ester(134420-70-5)

Safety Data

• Hazardous Substances Data: 134420-70-5(Hazardous Substances Data)

Upstream product

• 1161747-24-5 3-dibenzylamino-5-phenyl-pent-4-ynoic acid ethyl ester 
• 247242-35-9 ethyl 3-amino-5-phenylpent-2-enoate 
• 17071-29-3 ethyl 3-oxo-5-phenylpentanoate 

Downstream Products

• 1090904-04-3 (S)-3-amino-5-phenylpentanoic acid 
• 147228-37-3 (3R)-3-amino-5-phenylpentanoic acid 
• 134420-90-9 6-phenethylguvacine hydrochloride 
• 134420-77-2 ethyl N-(tert-butyloxycarbonyl)-N-(2-carbethoxyethyl)-3-amino-5-phenylvalerate 
• 134420-81-8 N-(tert-butyloxycarbonyl)-2-phenethyl-5-carbethoxy-4-piperidone 
• 134420-85-2 N-(tert-butyloxycarbonyl)-2-phenethyl-5-carbethoxy-1,2,3,6-tetrahydropyridine 
• 499194-28-4 (2-bromo-2-propenyl)-(3-phenylseleno-1-phenylethylpropyl)amine 
• 499193-87-2 3-[N-(2-bromo-2-propenyl)amino]-5-phenylpentan-1-ol 
• 357289-97-5 N-[1-(2-phenylselenoethyl)-3-phenylpropyl]-2-methyleneaziridine 
• 134420-72-7 ethyl N-(2-carbethoxyethyl)-3-amino-5-phenylvalerate 

Relevant articles and documents

Improved enzymatic syntheses of valuable β-arylalkyl-β-amino acid enantiomers

The enantioselective (E～ 200) Burkholderia cepacia-catalysed hydrolyses of β-amino esters with H2O (0.5 equiv.) in t-BuOMe or in i-Pr2O at 45 °C are described. The enantiomers of biologically relevant β-arylalkyl-substituted β-amino acids, and especially (R)-3-amino-3-(2,4,5-trifluorophenyl)butanoic acid, the intermediate of the new antidiabetic drug sitagliptine, were prepared with high enantiomeric excesses (ee≥96%) and in good yields (≥42%). The Royal Society of Chemistry 2010.

Efficient synthesis of γ,δ-alkynyl-β-amino acid derivatives by a new copper-catalyzed amine-alkyne-alkyne addition reaction

A simple and efficient method for the synthesis of γ,δ-alkynyl- β-amino acid derivatives by a new copper-catalyzed amines-alkynes-alkynes addition was developed. Various γ,δ-alkynyl-β-amino acid derivatives were obtained in moderate to good yields in one step.