134420-78-3

Basic information

• Product Name: ethyl N-(tert-butyloxycarbonyl)-N-(2-carbethoxyethyl)-3-amino-6,6-diphenylcaproate
• Synonyms: ethyl N-(tert-butyloxycarbonyl)-N-(2-carbethoxyethyl)-3-amino-6,6-diphenylcaproate
• CAS NO: 134420-78-3
• Molecular Weight: 511.659
• Mol File: 134420-78-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl N-(tert-butyloxycarbonyl)-N-(2-carbethoxyethyl)-3-amino-6,6-diphenylcaproate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl N-(tert-butyloxycarbonyl)-N-(2-carbethoxyethyl)-3-amino-6,6-diphenylcaproate(134420-78-3)
• EPA Substance Registry System: ethyl N-(tert-butyloxycarbonyl)-N-(2-carbethoxyethyl)-3-amino-6,6-diphenylcaproate(134420-78-3)

Safety Data

• Hazardous Substances Data: 134420-78-3(Hazardous Substances Data)

Upstream product

• 134420-95-4 ethyl 3-(benzylamino)-6,6-diphenylcaproate 
• 134420-71-6 ethyl 3-amino-6,6-diphenylcaproate 
• 134420-92-1 ethyl 6,6-diphenyl-2-hexenoate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 134420-73-8 ethyl N-(2-carbethoxyethyl)-3-amino-6,6-diphenylcaproate 

Downstream Products

• 134420-88-5 2-(3,3-diphenylpropyl)-5-carbethoxy-1,2,3,6-tetrahydropyridine hydrochloride 
• 134420-91-0 6-(3,3-diphenylpropyl)guvacine hydrochloride 
• 134420-86-3 N-(tert-butyloxycarbonyl)-2-(3,3-diphenylpropyl)-5-carbethoxy-1,2,3,6-tetrahydropyridine 
• 134420-82-9 N-(tert-butyloxycarbonyl)-2-(3,3-diphenylpropyl)-5-carbethoxy-4-piperidone 

Relevant articles and documents

GABA-uptake inhibitors: Construction of a general pharmacophore model and successful prediction of a new representative

A model for the pharmacophore of GABA-uptake inhibitors was established using published structure-activity data and molecular modeling. The model accounted for the activities of different classes of GABA-uptake inhibitors. Analogues of guvacine substituted at position 6 were synthesized in order to confirm the model. 6-(3,3-Diphenylpropyl)guvacine (30f), which fit well with the pharmacophore, had an in vitro IC50 of 0.1 μM. This value is as good as those of the best GABA-uptake inhibitors known today.