134424-35-4Relevant academic research and scientific papers
An easy synthesis of α-trifluoromethyl-amines from aldehydes or ketones using the Ruppert-Prakash reagent
Radchenko, Dmytro S.,Michurin, Oleg M.,Chernykh, Anton V.,Lukin, Oleg,Mykhailiuk, Pavel K.
, p. 1897 - 1898 (2013/04/24)
A small library of structurally diverse primary amines bearing a geminal CF3 group was synthesized on a preparative scale. The synthesis starts with an aldehyde or ketone that reacts with benzylamine yielding the corresponding imine. The latter is then trifluoromethylated with Me 3SiCF3 under acidic conditions to give a benzylalkylamine. In the last step the Pd-mediated hydrogenation of the benzylalkylamines furnishes the title compounds. All synthetic steps are high-yielding; neither the isolation of the intermediates nor the chromatographic purification of the products is necessary.
Fluorinated cyclohexane derivatives, process and intermediates for their preparation and the use of the new fluorinated cyclohexane derivatives as fungicides and intermediates
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, (2008/06/13)
The present invention relates to new fluorinated cyclohexane derivatives of the formula STR1 in which the symbols used have the meaning indicated in the description, a process for their preparation, intermediates of the formula STR2 in which the symbols h
