134432-60-3

Usage

Uses

Used in Organic Synthesis:
2-(2,3-DIMETHYLPHENOXY)ACETOHYDRAZIDE serves as a building block in organic synthesis, allowing for the creation of various complex organic molecules. Its unique structure and functional groups make it a valuable component in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Medicinal Chemistry:
2-(2,3-DIMETHYLPHENOXY)ACETOHYDRAZIDE has been reported to possess potential medicinal properties, such as anti-inflammatory and anti-tumor effects. Its hydrazide functional group and the presence of methyl groups on the benzene ring may contribute to its biological activity, making it a promising candidate for further research and development in the field of drug discovery.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-(2,3-DIMETHYLPHENOXY)ACETOHYDRAZIDE is used as a starting material or intermediate in the synthesis of drugs with potential therapeutic applications. Its unique chemical structure and properties can be leveraged to develop new drugs with improved efficacy and safety profiles.
Safety Precautions:
It is important to handle 2-(2,3-DIMETHYLPHENOXY)ACETOHYDRAZIDE with care, as it may be harmful if ingested or inhaled, and can cause irritation to the skin and eyes. Proper safety measures, such as wearing protective clothing and using appropriate containment and ventilation systems, should be implemented during its use and handling.

InChI:InChI=1/C10H14N2O2/c1-7-4-3-5-9(8(7)2)14-6-10(13)12-11/h3-5H,6,11H2,1-2H3,(H,12,13)

Upstream product

• 526-75-0 2,3-Dimethylphenol 
• 16861-31-7 ethyl [(2,3-dimethylphenyl)oxy]acetate 
• 57296-55-6 methyl 2-(2,3-dimethylphenoxy)acetate 
• 302-01-2 hydrazine 

Downstream Products

• 1572184-49-6 C₁₉H₁₉N₃O₂ 
• 1572184-48-5 (E)-N’-((1H-indol-4-yl)methylene)-2-(2,3-dimethylphenoxy)acetohydrazide 
• 1263183-99-8 C₁₁H₁₅N₃O₂S 
• 1263183-89-6 C₁₅H₁₅N₃O₂S 
• 123217-00-5 5-(2,3-dimethyl-phenoxymethyl)-[1,3,4]thiadiazol-2-ylamine 

Relevant academic research and scientific papers

N-ACYLHYDRAZONE DERIVATIVES FOR SELECTIVE T CELL INHIBITOR AND ANTI-LYMPHOID MALIGNANCY DRUG

The present invention relates to novel N-acylhydrazone derivatives, and more particularly to novel N-acylhydrazone derivatives having selective T cell inhibitory activity and/or anti-lymphoid malignancy activity, stereoisomers thereof, pharmaceutically acceptable salts thereof, the use thereof for preparing pharmaceutical compositions, pharmaceutical compositions containing the same, treatment methods using the compositions, and methods for preparing the novel N-acylhydrazone derivatives.

Synthesis and xanthine oxidase inhibitory activity of 7-methyl-2- (phenoxymethyl)-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one derivatives

An elevated level of blood uric acid (hyperuricemia) is the underlying cause of gout. Xanthine oxidase is the key enzyme that catalyzes the oxidation of hypoxanthine to xanthine and then to uric acid. Allopurinol, a widely used xanthine oxidase inhibitor is the most commonly used drug to treat gout. However, a small but significant portion of the population suffers from adverse effects of allopurinol that includes gastrointestinal upset, skin rashes and hypersensitivity reactions. Moreover, an elevated level of uric acid is considered as an independent risk factor for cardiovascular diseases. Therefore use of allopurinol-like drugs with minimum side effects is the ideal drug of choice against gout. In this study, we report the synthesis of a series of pyrimidin-5-one analogues as effective and a new class of xanthine oxidase inhibitors. All the synthesized pyrimidin-5-one analogues are characterized by spectroscopic techniques and elemental analysis. Four (6a, 6b, 6d and 6f) out of 20 synthesized molecules in this class showed good inhibition against three different sources of xanthine oxidase, which were more potent than allopurinol based on their respective IC50 values. Molecular modeling and docking studies revealed that the molecule 6a has very good interactions with the Molybdenum-Oxygen-Sulfur (MOS) complex a key component in xanthine oxidase. These results highlight the identification of a new class of xanthine oxidase inhibitors that have potential to be more efficacious, than allopurinol, to treat gout and possibly against cardiovascular diseases.