57296-55-6Relevant academic research and scientific papers
N-ACYLHYDRAZONE DERIVATIVES FOR SELECTIVE T CELL INHIBITOR AND ANTI-LYMPHOID MALIGNANCY DRUG
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Page/Page column 50; 51, (2014/03/25)
The present invention relates to novel N-acylhydrazone derivatives, and more particularly to novel N-acylhydrazone derivatives having selective T cell inhibitory activity and/or anti-lymphoid malignancy activity, stereoisomers thereof, pharmaceutically acceptable salts thereof, the use thereof for preparing pharmaceutical compositions, pharmaceutical compositions containing the same, treatment methods using the compositions, and methods for preparing the novel N-acylhydrazone derivatives.
Phenoxyacetic acids as PPARδ partial agonists: Synthesis, optimization, and in vivo efficacy
Evans, Karen A.,Shearer, Barry G.,Wisnoski, David D.,Shi, Dongchuan,Sparks, Steven M.,Sternbach, Daniel D.,Winegar, Deborah A.,Billin, Andrew N.,Britt, Christy,Way, James M.,Epperly, Andrea H.,Leesnitzer, Lisa M.,Merrihew, Raymond V.,Xu, Robert X.,Lambert, Millard H.,Jin, Jian
supporting information; experimental part, p. 2345 - 2350 (2011/06/17)
A series of phenoxyacetic acids as subtype selective and potent hPPARδ partial agonists is described. Many analogues were readily accessible via a single solution-phase synthetic route which resulted in the rapid identification of key structure-activity r
Le polyphosphate d'ethyle, un reactif de choix pour la synthese de derives du benzofuranne dicarboxylate-2,3 de methyle
Belleney, Joel,Vebrel, Joel,Cerutti, Ernest
, p. 1431 - 1435 (2007/10/02)
The aim of this work is to develop a fast and effective method for the synthesis of methylated derivatives of dimethylbenzofuran-2,3-dicarboxylate.With this end in view, we can suggest significant improvements to the Koelsch and Whitney method, especially by using ethyl polyphosphate.This reagent is indeed well adapted to the cyclodehydration of the methyl 2-aryloxy-3-hydroxymaleate intermediates into benzofuran compounds, since the yield is often better than 80percent.
