134435-17-9Relevant academic research and scientific papers
Preparation of Tricarbonyl(η6-pyridine)chromium(0) Complexes
Davies, Stephen G.,Shipton, Mark R.
, p. 501 - 507 (1991)
The synthesis of tricarbonyl(η6-pyridine)chromium(0) complexes is accomplished via complexation of 2-silylpyridines with subsequent fluoride ion-mediated desilylation under mild conditions.The tricarbonylchromium(0) complexes of pyridine, 2-methylpyridine, 3-methylpyridine, 2-ethylpyridine, 2-(but-3-enyl)pyridine and 2-(6-trimethylsilylpyridyl)-1,3-dioxolane are prepared.Deprotonation (lithium diisopropylamide) and methylation (methyl iodide) of tricarbonyl(η6-pyridine)chromium(0) converts it cleanly to tricarbonyl(η6-2-methylpyridine)chromium(0).
Photochemical C-H Silylation and Hydroxymethylation of Pyridines and Related Structures: Synthetic Scope and Mechanisms
Rammal, Fatima,Gao, Di,Boujnah, Sondes,Hussein, Aqeel A.,Lalevée, Jacques,Gaumont, Annie-Claude,Morlet-Savary, Fabrice,Lakhdar, Sami
, p. 13710 - 13717 (2020/11/30)
Considering the synthetic relevance of heteroarenes in various areas ranging from organic synthesis to medicinal chemistry, developing practically simple methodologies to access functionalized heteroarenes is of a significant value. Described herein is an efficient approach for C-H silylation and hydroxymethylation of pyridines and related heterocycles by the combination of silanes or methanol with readily available N-methoxypyridinium ions with a low catalyst loading (2 mol %) under blue light irradiation. The synthetic importance of the developed reactions is demonstrated by the synthesis of biologically relevant compounds. Electron paramagnetic resonance spectroscopy, quantum yield measurements, and density-functional theory calculations allowed us to understand reaction mechanisms of both photocatalytic reactions.
Palladium-mediated olefination of 2-(tert-butyldimethylsilyl)pyridine by sp3 C-H activation
Wang, Cong,Ge, Haibo
experimental part, p. 2590 - 2594 (2011/10/02)
An unprecedented direct alkenylation of 2-(tert-butyl-dimethylsilyl) pyridine with acrylates through palladium-mediated C-H activation on a nonacidic sp3 carbon is reported. This method provides an efficient approach to allylsilanes. Georg Thie
