134435-46-4Relevant academic research and scientific papers
Highly Chemoselective gem-Difluoropropargylation of Aliphatic Alcohols
Okamura, Toshitaka,Egoshi, Syusuke,Dodo, Kosuke,Sodeoka, Mikiko,Iwabuchi, Yoshiharu,Kanoh, Naoki
supporting information, p. 16002 - 16006 (2019/11/19)
Despite the potential of α-fluoroethers in medicinal chemistry, their synthetic methods, especially etherification of aliphatic alcohols, have been limited. Herein, we developed two- and three-step gem-difluoropropargylation of aliphatic alcohols includin
N-ALKOXYALKYL-N,N-DIALKYLAMINE DERIVATIVES OR SALTS THEREOF, AND REMEDIES FOR NERVE DEGENERATION DISEASES CONTAINING THE SAME
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Example 10'(1), (2008/06/13)
An N-alkoxyalkyl-N,N-dialkylamine derivative represented by the following general formula [1]: wherein the ring D represents a 5- or 6-membered heterocyclic ring or hydrocarbon ring; R3 and R4, which are the same or different, represent an unsubstituted or substituted alkyl, cycloalkyl or aralkyl group; and R1, R2, R5, R6, R7, R8, m and n are as defined in the specification, or a salt thereof has an anti-hypoxic activity, a nerve-protecting activity and a nerve regeneration promoting activity and is useful for the treatment of neurodegenerative diseases.
Synthesis of 12-O-methyl-2a-methoxyferruginol
Burnell, Robert H.,Desfosses, Sonia
, p. 355 - 360 (2007/10/03)
A rapid synthesis of 12-O-methyl-2-methoxyferruginol (1) shows it not to be identical with the natural product ascribed this structure.
Synthesis of aromatic diterpenes synthesis of 12-hydroxy-abieta-8,11,13-trien-3,7-dione
Burnell,Caron
, p. 127 - 132 (2007/10/02)
Model studies involving cationic cyclisation of suitable dienes have provided a synthesis of the title compound. Preparation of the dienes from available aromatic starting materials and the modification of the cyclised products are described.
