1344673-84-2

Upstream product

• 890027-87-9 (S,E)-(6-iodo-4-((methoxymethoxy)methyl)-4-methylhex-2-enyl)trimethylsilane 
• 890027-86-8 (S,E)-3-((methoxymethoxy)methyl)-3-methyl-6-(trimethylsilyl)hex-4-en-1-ol 
• 890027-84-6 ((S,E)-6-(1-ethoxyethoxy)-4-((methoxymethoxy)methyl)-4-methylhex-2-enyl)trimethylsilane 
• 890027-56-2 (4S,E)-1-chloro-6-(1-ethoxyethoxy)-4-((methoxymethoxy)methyl)-4-methylhex-2-ene 
• 890027-82-4 (4S,E)-6-(1-ethoxyethoxy)-4-((methoxymethoxy)methyl)-4-methylhex-2-en-1-ol 
• 890027-80-2 (4S,E)-ethyl 6-(1-ethoxyethoxy)-4-((methoxymethoxy)methyl)-4-methylhex-2-enoate 
• 890027-54-0 (2R)-4-(1-ethoxyethoxy)-2-((methoxymethoxy)methyl)-2-methylbutanal 
• 890027-78-8 (2S)-4-(1-ethoxyethoxy)-2-((methoxymethoxy)methyl)-2-methylbutan-1-ol 
• 890027-76-6 (R)-4-(1-ethoxyethoxy)-2-((methoxymethoxy)methyl)-2-methylbutyl acetate 
• 890027-50-6 (R)-acetic acid 4-hydroxy-2-methoxymethoxymethyl-2-methylbutyl ester 
• 890027-74-4 (E)-(R)-acetic acid 2-methoxymethoxymethyl-2-methyl-5-phenylpent-4-enyl ester 
• 189884-53-5 2-methyl-2-(3-phenyl-2-propenyl)malonic acid dimethyl ester 
• 890027-47-1 (S,E)-2-((methoxymethoxy)methyl)-2-methyl-5-phenylpent-4-en-1-ol 
• 890027-72-2 (E)-(R)-2-methoxymethoxymethyl-2-methyl-5-phenylpent-4-enoic acid methyl ester 

Downstream Products

• 4611-05-6 Ophiobolin A 
• 1344673-75-1 2-[(2R,4S,5S,6R,7S)-2-tert-butyldiphenylsilyloxymethyl-7-formyl-4,7-dimethyl-1-oxaspiro[4.4]non-6-yl]ethyl pivalate 
• 1344673-73-9 (1R,2S,3S,4S)-4-(benzyloxy)-2-{[(2R,4S,5S,6R,7R)-2-({[tert-butyl(dimethyl)silyl]oxy}methyl)-4,7-dimethyl-6-prop-2-en-1-yl-1-oxaspiro[4.4]non-7-yl]methyl}-3-[1-(hydroxymethyl)ethenyl]-1-methylcyclopentanol 
• 1344673-81-9 2-{(1S,2S,3R,5S)-2-{[(2R,4S,5S,6R,7R)-6-allyl-2-({[tert-butyl(diphenyl)silyl]oxy}methyl)-4,7-dimethyl-1-oxaspiro[4.4]non-7-yl]methyl}-5-{[tert-butyl(diphenyl)silyl]oxy}-3-methyl-3-[(trimethylsilyl)oxy]cyclopentyl}prop-2-en-1-ol 
• 1344673-80-8 1-{(1R,2S,3R,5S)-2-{[(2R,4S,5S,6R,7R)-6-allyl-2-tert-butyldiphenylsilyloxymethyl-4,7-dimethyl-1-oxaspiro[4.4]non-7-yl]methyl}-5-tert-butyldiphenylsilyloxy-3-methyl-3-trimethylsilyloxycyclopentyl}ethanone 
• 1344673-95-5 1-((1R,2S,3R,5S)-2-{[(2R,4S,5S,6R,7R)-6-allyl-2-tert-butyldiphenylsilyloxymethyl-4,7-dimethyl-1-oxaspiro[4.4]non-7-yl]methyl}-5-tert-butyldiphenylsilyloxy-3-hydroxy-3-methylcyclopentyl)ethanone 
• 1344673-79-5 (1R,2S,3S,4S)-2-{[(2R,4S,5S,6R,7R)-6-allyl-2-tert-butyldiphenylsilyloxymethyl-4,7-dimethyl-1-oxaspiro[4.4]non-7-yl]methyl}-4-tert-butyldiphenylsilyloxy-3-hydroxymethyl-1-methylcyclopentanol 
• 1344673-94-4 (1R,2S,3S,4S)-2-{[(2R,4S,5S,6R,7R)-6-allyl-2-tert-butyldiphenylsilyloxymethyl-4,7-dimethyl-1-oxaspiro[4.4]non-7-yl]methyl}-3-tert-butyldimethylsilyloxymethyl-4-tert-butyldiphenylsilyloxy-1-methylcyclopentanol 
• 1344673-93-3 [(2R,4S,5S,6R,7R)-7-[((1S,2R,4S,5S)-5-tert-butyldimethylsilyloxymethyl-4-tert-butyldiphenylsilyloxy-2-hydroxy-2-methylcyclopentyl)methyl]-2-tert-butyldiphenylsilyloxymethyl-4,7-dimethyl-1-oxaspiro[4.4]non-6-yl]acetaldehyde 

Relevant academic research and scientific papers

Enantioselective total synthesis of (+)-ophiobolin A

The enantioselective total synthesis of (+)-ophiobolin A is described. This total synthesis features the construction of the spiro CD ring of (+)-ophiobolin A through a stereoselective intramolecular Hosomi-Sakurai cyclization reaction, the joining of the

Convergent total synthesis of (+)-ophiobolin A

At long last: The enantioselective total synthesis of the title compound, which was isolated in 1958, proceeds by a convergent approach. The assembly of the C,D-ring fragment and the A-ring fragment of the core structure is achieved by employing a Reforma