1344675-56-4Relevant articles and documents
Investigation of the pyrazinones as PDE5 inhibitors: Evaluation of regioisomeric projections into the solvent region
Hughes, Robert O.,Maddux, Todd,Rogier, D. Joseph,Lu, Sharon,Walker, John K.,Jacobsen, E. Jon,Rumsey, Jeanne M.,Zheng, Yi,MacInnes, Alan,Bond, Brian R.,Han, Seungil
, p. 6348 - 6352 (2011/11/29)
We describe the design, synthesis and profiling of a novel series of PDE5 inhibitors. We take advantage of an alternate projection into the solvent region to identify compounds with excellent potency, selectivity and pharmacokinetic profiles.