1344682-09-2Relevant academic research and scientific papers
Synthesis of α-trifluoromethyl-β-keto phosphonates by electrophilic trifluoromethylation with Togni reagent
Fu, Wen-Zhi,Huang, Yangen,Xu, Xiu-Hua,Qing, Feng-Ling
, p. 415 - 420 (2016)
A new synthetic method of trifluoromethylated phosphonates was developed via electrophilic trifluoromethylation with Togni reagent. A variety of β-keto phosphonates were converted into the corresponding α-trifluoromethyl-β-keto phosphonates in moderate to good yields. This protocol could also be extended to other fluoroalkylation reactions, such as pentafluoroethylation.
Β-carbonyl process for the preparation of phosphonic acid ester compound
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Paragraph 0109-0111, (2016/12/01)
The present invention discloses a preparation method for preparing beta-Ketophosphonates represented by a formula (III). The beta-Ketophosphonate is an oxygen-containing compound having a value, and is especially adopted as an important synthesis intermediate to be widely used in the famous HWE reaction to synthesize alpha,beta-unsaturated carbonyl compounds. According to the present invention, simple and commercialized olefin and hydrogen-phosphorite are adopted as raw materials to directly utilize oxygen as an oxidizing agent and an oxygen source under transition metal catalysis to prepare the beta-Ketophosphonates; the preparation method has advantages of cheap and easily available raw materials, mild reaction conditions, environmental-friendliness, high atom economy, wide substrate adaptability range, and no requirement of harsh reaction conditions such as equivalent organic metal reagent use, low temperature, no water, no oxygen and the like; and the method further has advantages of short preparation period, easy product purification, stable process conditions, convenient operation and safety, and is suitable for large-scale production.
Catalytic and direct oxyphosphorylation of alkenes with dioxygen and H-phosphonates leading to β-ketophosphonates
Wei, Wei,Ji, Jian-Xin
scheme or table, p. 9097 - 9099 (2011/10/12)
Direct access: The title reaction has been developed under mild reaction conditions (see scheme; DMSO=dimethyl sulfoxide). This reaction can be effectively scaled up and offers not only a green and attractive approach to β-ketophosphonates, but also a useful example of direct incorporation of an oxygen atom from dioxygen into organic frameworks. Copyright
