1344685-84-2

Upstream product

• 434-64-0 perfluorotoluene 
• 651-83-2 4-trifluoromethyl-2,3,5,6-tetrafluoroaniline 
• 609-65-4 o-chlorobenzoyl chloride 
• 118-91-2 ortho-chlorobenzoic acid 
• 80588-64-3 N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)benzamide 
• 1352238-53-9 (CH₃)4C₂O₂BC₆H₄CONHC₆F₄CF₃ 

Downstream Products

• 1344685-93-3 2-chloro-6-fluoro-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)benzamide 
• 1352238-62-0 (CH₃)4C₂O₂BC₆H₃ClCONHC₆F₄CF₃ 
• 1465827-35-3 2-chloro-6-morpholino-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)benzamide 
• 1446442-56-3 2-chloro-6-iodo-N-[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]benzamide 

Relevant academic research and scientific papers

PALLADIUM(II)-CATALYZED SELECTIVE FLUORINATION OF BENZOIC ACIDS AND DERIVATIVES

A new method of ortho-fluorination for selectively fluorinating a benzoic acid or derivative compound where an aryl C—H bond is directly replaced by an aryl C—F bond is provided. The method comprises reacting a compound having the formula: wherein X is at

Ligand-promoted alkylation of C(sp3)-H and C(sp2)-H bonds

9-Methylacridine was identified as a generally effective ligand to promote a Pd(II)-catalyzed C(sp3) - H and C(sp2) - H alkylation of simple amides with various alkyl iodides. This alkylation reaction was applied to the preparation of unnatural amino acids and geometrically controlled tri- and tetrasubstituted acrylic acids.

Pd-catalyzed oxidative ortho -C-H borylation of arenes

The development of a Pd-catalyzed oxidative ortho-C-H borylation with N-arylbenzamides is reported. A modified dibenzylideneacetone (dba) ligand, a weak base, and a strong oxidant are critical for obtaining good yields. The reaction is tolerant of electro

Pd(II)-catalyzed ortho trifluoromethylation of arenes and insights into the coordination mode of acidic amide directing groups

A Pd(II)-catalyzed trifluoromethylation of ortho C-H bonds with an array of N-arylbenzamides derived from benzoic acids is reported. N-Methylformamide has been identified as a crucial promoter of C-CF3 bond formation from the Pd center. X-ray characterization of the C-H insertion intermediate has revealed a rare coordination mode of acidic amides as directing groups and the origin of their capacity in directing C-H activation.

Palladium(II)-catalyzed selective monofluorination of benzoic acids using a practical auxiliary: A weak-coordination approach

Finally, a choice! A highly selective palladium(II)-catalyzed ortho-monofluorination reaction has been achieved for the first time through a weak coordination (see scheme; Ar=2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl) . Simple modification of this protocol allows for a choice between mono- and difluorination. The mono- and difluorinated benzoic acid derivatives are valuable in the pharmaceutical and agrochemical industries. Copyright