1344698-01-6

Upstream product

• 146-77-0 2-Chloroadenosine 
• 883731-55-3 2-chloro-9-[5-deoxy-2,3-O-(1-methylethylidene)-β-D-ribofuranosyl]-9H-purin-6-amine 
• 108-95-2 phenol 
• 53458-44-9 2-chloro-O^{2'_,O3'_{-isopropylidene-O}5'}-(toluene-4-sulfonyl)-adenosine 
• 24639-06-3 ((3aR,4R,6R,6aR)-6-(6-amino-2-chloro-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol 

Relevant academic research and scientific papers

Discovery of bacterial NAD+-dependent DNA ligase inhibitors: Optimization of antibacterial activity

Optimization of adenosine analog inhibitors of bacterial NAD +-dependent DNA ligase is discussed. Antibacterial activity against Streptococcus pneumoniae and Staphylococcus aureus was improved by modification of the 2-position substituent on the adenine ring and 3′- and 5′-substituents on the ribose. Compounds with log D values 1.5-2.5 maximized potency and maintained drug-like physical properties.