1344700-14-6

Basic information

• Product Name: (2S)-2-(4-iodo-N-methylbenzamide)-N¹,2-dimethyl-N³-((tetrahydro-2H-pyran-2-yl)oxy)malonamide
• Synonyms: (2S)-2-(4-iodo-N-methylbenzamide)-N¹,2-dimethyl-N³-((tetrahydro-2H-pyran-2-yl)oxy)malonamide
• CAS NO: 1344700-14-6
• Molecular Weight: 489.31
• Mol File: 1344700-14-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (2S)-2-(4-iodo-N-methylbenzamide)-N¹,2-dimethyl-N³-((tetrahydro-2H-pyran-2-yl)oxy)malonamide(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-2-(4-iodo-N-methylbenzamide)-N¹,2-dimethyl-N³-((tetrahydro-2H-pyran-2-yl)oxy)malonamide(1344700-14-6)
• EPA Substance Registry System: (2S)-2-(4-iodo-N-methylbenzamide)-N¹,2-dimethyl-N³-((tetrahydro-2H-pyran-2-yl)oxy)malonamide(1344700-14-6)

Safety Data

• Hazardous Substances Data: 1344700-14-6(Hazardous Substances Data)

Upstream product

• 6723-30-4 O-2-tetrahydro-2H-pyranhydroxylamine 
• 1344700-13-5 1-{[(2S)-2-carboxy-1-(methylamino)-1-oxopropan-2-yl](methyl)carbamolyl}-4-iodobenzene 
• 1344700-12-4 1-{[(2S)-1-ethoxy-2-methyl-3-(methylamino)-1,3-dioxopropan-2-yl](methyl)carbamolyl}-4-iodobenzene 
• 1711-02-0 4-iodobenzoic acid chloride 

Downstream Products

• 1344700-62-4 (2S)-N,2-dimethyl-2-[methyl(4-{[4-(1,4-oxazepan-4-ylmethyl)phenyl]ethynyl}benzoyl)amino]-N'-(tetrahydro-2H-pyran-2-yloxy)propanediamide 
• 1344697-16-0 (2S)-N-hydroxy-N',2-dimethyl-2-{methyl[(4-{[4-(1,4-oxazepan-4-ylmethyl)phenyl]ethynyl}phenyl)carbonyl]amino}propanediamide 
• 1344700-65-7 (2S)-2-[{4-[(4-{[3-(2-fluoroethoxy)azetidin-1-yl]methyl}phenyl)ethynyl]benzoyl}(methyl)amino]-N,2-dimethyl-N'-(tetrahydro-2H-pyran-2-yloxy)propanediamide 
• 1344700-77-1 (2S)-2-[(4-{[5-(methoxymethyl)furan-3-yl]ethynyl}benzoyl)(methyl)amino]-N,2-dimethyl-N'-(tetrahydro-2H-pyran-2-yloxy)propanediamide 
• 1344699-11-1 (2S)-N-hydroxy-2-{[(4-{[5-(methoxymethyl)furan-3-yl]ethynyl}phenyl)carbonyl](methyl)amino}-N'2-dimethylpropanediamide 

Relevant articles and documents

METHOD FOR USING NOVEL HYDROXAMIC ACID DERIVATIVE AND ANTIBACTERIAL SUBSTANCE IN COMBINATION

Pharmacological compositions containing a hydroxamic acid derivative selected from (2S)-2-((4-((4-((1S)-1,2-dihydroxyethyl)phenyl)ethynyl)benzoyl)(methyl)amino)-N-hydroxy-N',2-dimethylmalonamide, (2S)-2-((4-((4-((1R)-1,2-dihydroxyethyl)phenyl)ethynyl)benzoyl)(methyl)amino)-N-hydroxy-N',2-dimethylmalonamide, and (2S)-N-hydroxy-2-((4-((4-((1S)-1-hydroxy-2-methoxyethyl)phenyl)ethynyl)benzoyl)(methyl)amino)-N',2-dimethylmalonamide, or a salt of said derivatives, and an antibiotic substance are useful in the treatment of gram-negative bacterial infections.

MANUFACTURING METHOD OF NOVEL HYDROXAMIC ACID DERIVATIVE

PROBLEM TO BE SOLVED: To provide an industrial manufacturing method of a compound high in optical purity and having excellent uridyldiphospho-3-O-acyl-N acetylglucosamine deacetylase (LpxC) inhibitory activity. SOLUTION: There is provided a manufacturing method of a compound having a LpxC inhibitory activity represented by (2S)-2-((4-((4-((1S-1,2-dihydroxyethyl)phenyl)ethynyl)benzoyl)(methyl)amino)-N-hydroxy-N',2-dimethyl malonamide or a salt, of which an intermediate is represented by the formula [3] or [4], where R1 and R2 are each independently substituted/unsubstituted C1-6 alkyl group, Ra is an amino protective group, Rb is a carboxyl protective group and Rc is a hydroxyl protective group. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT