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134471-24-2

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134471-24-2 Usage

Uses

7-Hydroxycoumarin-3-carboxylic acid N-succinimidyl ester is a compound suitable for fluorescence.

Check Digit Verification of cas no

The CAS Registry Mumber 134471-24-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,4,4,7 and 1 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 134471-24:
(8*1)+(7*3)+(6*4)+(5*4)+(4*7)+(3*1)+(2*2)+(1*4)=112
112 % 10 = 2
So 134471-24-2 is a valid CAS Registry Number.
InChI:InChI=1/C14H9NO7/c16-8-2-1-7-5-9(13(19)21-10(7)6-8)14(20)22-15-11(17)3-4-12(15)18/h1-2,5-6,16H,3-4H2

134471-24-2 Well-known Company Product Price

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  • TCI America

  • (S0866)  N-Succinimidyl 7-Hydroxycoumarin-3-carboxylate  >96.0%(HPLC)(T)

  • 134471-24-2

  • 200mg

  • 1,590.00CNY

  • Detail
  • TCI America

  • (S0866)  N-Succinimidyl 7-Hydroxycoumarin-3-carboxylate  >96.0%(HPLC)(T)

  • 134471-24-2

  • 1g

  • 4,990.00CNY

  • Detail
  • Sigma

  • (55156)  7-Hydroxycoumarin-3-carboxylic acid N-succinimidyl ester  suitable for fluorescence, ≥95.0% (coupling assay to aminopropyl silica gel)

  • 134471-24-2

  • 55156-25MG-F

  • 1,506.96CNY

  • Detail
  • Sigma

  • (55156)  7-Hydroxycoumarin-3-carboxylic acid N-succinimidyl ester  suitable for fluorescence, ≥95.0% (coupling assay to aminopropyl silica gel)

  • 134471-24-2

  • 55156-100MG-F

  • 5,064.93CNY

  • Detail

134471-24-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name (2,5-dioxopyrrolidin-1-yl) 7-hydroxy-2-oxochromene-3-carboxylate

1.2 Other means of identification

Product number -
Other names Umbelliferone-3-carboxylic acid N-succinimidyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:134471-24-2 SDS

134471-24-2Relevant articles and documents

COUMARIN-BASED CROSSLINKING REAGENTS

-

Paragraph 0348; 0349, (2020/04/25)

Disclosed herein are novel coumarin-based reagents, e.g. linkers, and conjugates including one or more of the disclosed coumarin-based reagents. In some embodiments, the presence of a coumarin moiety within the coumarin-based reagents enables detection of labels which are typically difficult to detect, e.g. certain haptens.

Structure-Activity Relationships of Potent, Targeted Covalent Inhibitors That Abolish Both the Transamidation and GTP Binding Activities of Human Tissue Transglutaminase

Akbar, Abdullah,McNeil, Nicole M. R.,Albert, Marie R.,Ta, Viviane,Adhikary, Gautam,Bourgeois, Karine,Eckert, Richard L.,Keillor, Jeffrey W.

supporting information, p. 7910 - 7927 (2017/10/06)

Human tissue transglutaminase (hTG2) is a multifunctional enzyme. It is primarily known for its calcium-dependent transamidation activity that leads to formation of an isopeptide bond between glutamine and lysine residues found on the surface of proteins, but it is also a GTP binding protein. Overexpression and unregulated hTG2 activity have been associated with numerous human diseases, including cancer stem cell survival and metastatic phenotype. Herein, we present a series of targeted covalent inhibitors (TCIs) based on our previously reported Cbz-Lys scaffold. From this structure-activity relationship (SAR) study, novel irreversible inhibitors were identified that block the transamidation activity of hTG2 and allosterically abolish its GTP binding ability with a high degree of selectivity and efficiency (kinact/KI > 105 M-1 min-1). One optimized inhibitor (VA4) was also shown to inhibit epidermal cancer stem cell invasion with an EC50 of 3.9 μM, representing a significant improvement over our previously reported "hit" NC9.

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