1344718-96-2Relevant academic research and scientific papers
Synthesis, Biological Activity, and ADME Properties of Novel S-DABOs/N-DABOs as HIV Reverse Transcriptase Inhibitors
Radi, Marco,Pagano, Mafalda,Franchi, Luigi,Castagnolo, Daniele,Schenone, Silvia,Casaluce, Gianni,Zamperini, Claudio,Dreassi, Elena,Maga, Giovanni,Samuele, Alberta,Gonzalo, Encarna,Clotet, Bonaventura,Este, Jose A.,Botta, Maurizio
experimental part, p. 883 - 896 (2012/08/08)
Previous studies aimed at exploring the SAR of C2-functionalized S-DABOs demonstrated that the substituent at this position plays a key role in the inhibition of both wild-type RT and drug-resistant enzymes, particularly the K103N mutant form. The introdu
A domino microwave-assisted protocol for the synthesis of 2,6-disubstituted pyrimidinones
Radi, Marco,Casaluce, Gianni,Botta, Maurizio
scheme or table, p. 1997 - 2000 (2011/10/09)
A practical microwave-assisted protocol for the synthesis of 2,6-disubstituted pyrimidinones has been developed. This approach is based on a domino Michael addition-cyclocondensation reaction between substituted thioureas/guanidines and acetylenecarboxyla
