134477-41-1

Upstream product

• 19008-71-0 8-aminooctan-1-ol 
• 501-53-1 benzyl chloroformate 
• 134477-39-7 8-<(benzyloxycarbonyl)amino>octan-1-ol 
• 50-00-0 formaldehyd 
• 134477-40-0 8-[(benzyloxycarbonyl)amino]octanal 

Downstream Products

• 134477-42-2 ethyl 5-<8-<(benzyloxycarbonyl)amino>oct-1-en-2-yl>oxazoline-4-carboxylate 
• 152564-55-1 ethyl (E)-10-<(benzyloxycarbonyl)amino>-4--2-(formylamino)dec-3-enoate 
• 134477-43-3 ethyl 10-<(benzyloxycarbonyl)amino>-2-(formylamino)-3-hydroxy-4-methylenedecanoate 
• 152564-54-0 ethyl (E)-10-<(benzyloxycarbonyl)amino>-4-(bromomethyl)-2-(formylamino)dec-3-enoate 

Relevant academic research and scientific papers

Synthesis and Binding Properties of 2-Amino-5-phosphono-3-pentenoic Acid Photoaffinity Ligands as Probes for the Glutamate Recognition Site of the NMDA Receptor

Four ω-benzoylated (E)-2,10-diamino-4-(phosphonomethyl)dec-3-enoic acids have been synthesized and tested in vitro for binding to the glutamate recognition site of the NMDA (N-methyl-D-aspartate) receptor.The ω-4-azidosalicylamide derivative 24 was iodinated to give the photoaffinity ligand 25 (CGP 55802 A) which showed an IC50 value of 34 nM in the in vitro 3H>CGP 39653 binding assay.This compound and its radioactive 125I-form are the first photoaffinity ligands for the NMDA receptor with high affinity to the glutamate recognition site.