134477-43-3

Upstream product

• 501-53-1 benzyl chloroformate 
• 134477-41-1 8-<(benzyloxycarbonyl)amino>-2-methyleneoctanal 
• 134477-40-0 8-[(benzyloxycarbonyl)amino]octanal 
• 134477-39-7 8-<(benzyloxycarbonyl)amino>octan-1-ol 
• 19008-71-0 8-aminooctan-1-ol 
• 134477-42-2 ethyl 5-<8-<(benzyloxycarbonyl)amino>oct-1-en-2-yl>oxazoline-4-carboxylate 

Downstream Products

• 152564-55-1 ethyl (E)-10-<(benzyloxycarbonyl)amino>-4--2-(formylamino)dec-3-enoate 
• 152564-54-0 ethyl (E)-10-<(benzyloxycarbonyl)amino>-4-(bromomethyl)-2-(formylamino)dec-3-enoate 

Relevant academic research and scientific papers

4-SUBSTITUTED 2-AMINOALK-3-ENOIC ACIDS

Substituted 2-aminoalk-3-enoic acid derivative of formula I STR1 wherein R 1 is an aliphatic hydrocarbon radical that is substituted by optionally acylated or aliphatically or araliphatically etherified hydroxy, by halogen, by optionally acylated and/or aliphatically substituted amino or by an aza-, diaza-, azoxa-or oxa-cycloaliphatic radical, or is an oxacycloaliphatic hydrocarbon radical bonded via a carbon atom, or is an optionally aliphatically N-substituted or N-acylated azacycloaliphatic hydrocarbon radical, and R. sub.2 is free or esterified carboxy, and their salts exhibit NMDA-antagonistic properties and are useful as active ingredients of anticonvulsive medicaments.

Synthesis and Binding Properties of 2-Amino-5-phosphono-3-pentenoic Acid Photoaffinity Ligands as Probes for the Glutamate Recognition Site of the NMDA Receptor

Four ω-benzoylated (E)-2,10-diamino-4-(phosphonomethyl)dec-3-enoic acids have been synthesized and tested in vitro for binding to the glutamate recognition site of the NMDA (N-methyl-D-aspartate) receptor.The ω-4-azidosalicylamide derivative 24 was iodinated to give the photoaffinity ligand 25 (CGP 55802 A) which showed an IC50 value of 34 nM in the in vitro 3H>CGP 39653 binding assay.This compound and its radioactive 125I-form are the first photoaffinity ligands for the NMDA receptor with high affinity to the glutamate recognition site.