134481-27-9

Upstream product

• 75999-66-5 N-(4-methoxyphenyl)trifluoroacetimidoyl chloride 
• 2314-97-8 iodotrifluoromethane 
• 10349-38-9 p-methoxyphenylisonitrile 
• 104-94-9 4-methoxy-aniline 
• 75999-66-5 (Z)-2,2,2-trifluoro-N-(4-methoxyphenyl)acetimidoyl chloride 

Downstream Products

• 144008-12-8 ethyl 3,3,3-trifluoro-2-((4-methoxyphenyl)imino)propanoate 
• 134481-19-9 (E)-5,5,5-Trifluoro-4-[(E)-4-methoxy-phenylimino]-pent-2-enoic acid methyl ester 
• 197508-14-8 (E)-4,4,4-Trifluoro-3-(4-methoxy-phenylamino)-1-phenyl-but-2-en-1-one 
• 204130-91-6 4-methoxy-N-(1,1,1-trifluoro-4-phenylbut-3-yn-2-ylidene)aniline 
• 204130-94-9 (4-Methoxy-phenyl)-[1-trifluoromethyl-3-trimethylsilanyl-prop-2-yn-(E)-ylidene]-amine 
• 104-94-9 4-methoxy-aniline 
• 278611-73-7 tert-butyl 2-[N-(p-methoxyphenyl)imino]-3,3,3-trifluoropropanoate 
• 1111327-69-5 C₁₇H₁₆F₃NO 
• 1111327-67-3 C₁₇H₂₀F₃NO 
• 1111327-43-5 C₁₈H₁₄F₃NO₂ 
• 1111327-66-2 C₁₈H₁₄F₃NO 
• 1352411-03-0 [Pd(η1-C(CF3)N(p-methoxyphenyl))(triphenylphosphine)2]4 
• 1352411-00-7 trans-Pd(η1-C(CF3)N(p-methoxyphenyl))(triphenylphosphine)2 

Relevant academic research and scientific papers

Selective formal transesterification of fluorinated 2-(trimethylsilyl)ethyl α-imino esters mediated by TBAF

(Chemical Equation Presented) The scope of the transesterification reaction between β-fluorinated α-imino esters and various electrophiles in the presence of TBAF as fluorine source is described. The reaction is highly selective for alkyl iodides, bromide

Synthesis of fluorinated allylic amines: Reaction of 2-(trimethylsilyl)ethyl sulfones and sulfoxides with fluorinated imines

A new synthesis of fluorinated allylamines through the reaction of 2-(trimethylsilyl)ethyl sulfones and sulfoxides (as vinyl anion equivalents) with imines and imino esters has been described. The process includes a TBAF-mediated fragmentation of 2-(trime

Palladium-catalyzed tert-butoxycarbonylation of trifluoroacetimidoyl iodides

A modification and details of the palladium-catalyzed tert-butoxycarbonylation of 2,2,2-trifluoroacetimidoyl iodides 1, which gave the iminocarboxylates 2, one of the promising precursors to fluorinated α-amino acids, are described. The Pd-catalyzed carbonylation reaction was remarkably promoted by the use of DMF or DMI as an additive, enough to achieve the selective formation of tert-butyl iminoesters. Nucleophilic alkylation of the imine moiety of 2 and subsequent removal of N- and O-protecting groups gave a variety of 2-substituted 2-amino-3,3,3-trifluoropropanoic acid derivatives 3 in high yields.

A new approach to polyfluoroalkyl imidoyl iodide

Polyfluoroalkyl imidoyl iodide were prepared by reaction of polyfluoroalkyl iodide with N-arylisocyanide in the presence of sulfinatodehalogenation reagent (Na2S2O4/Na2CO3).

Generation and Reactions of Trifluoroacetimidoyl Radicals

N-Aryltrifluoroacetimidoyl radicals have been generated by three different methods: the tin-radical promoted deiodination and photochemical homolysis of imidoyl iodides and the thermal homolysis of imidoyl azo-compounds.N-trifluoroace

One-Pot Synthesis of Trifluoroacetimidoyl Halides

Trifluoroacetimidoyl chlorides 1 were obtained in 80-90percent yields when a mixture of trifluoroacetic acid and a primary amine was heated in carbon tetrachloride in the presence of triphenylphosphine and triethylamine.The corresponding bromides 2 were o

Homologation of trifluoroacetimidoyl iodides by palladium-catalyzed carbonylation. An approach to α-amino perfluoroalkanoic acids

Homologation of trifluoroacetimidoyl iodides and the related perfluoro-compounds by palladium-catalyst under CO(1atm)-atmosphere in the presence of alcohols gives α-imino perfluoroalkanoates which are transformed to α-amino perfluoroalkanoic acids.

Palladium-catalyzed coupling reactions of trifluoroacetimidoyl iodides with olefins and 1-alkynes

Palladium-catalyzed coupling of trifluoroacetimidoyl iodides with olefins and 1-alkynes affords trifluoromethylated α-β-unsaturated imines, which are transformed into nitrogen heterocycles bearing CF3-group.