134481-27-9Relevant academic research and scientific papers
Selective formal transesterification of fluorinated 2-(trimethylsilyl)ethyl α-imino esters mediated by TBAF
Fustero, Santos,Sanchez-Rosello, Maria,Rodrigo, Vanessa,Garcia, Amador,Catalan, Silvia,Del Pozo, Carlos
, p. 5617 - 5620 (2008/12/21)
(Chemical Equation Presented) The scope of the transesterification reaction between β-fluorinated α-imino esters and various electrophiles in the presence of TBAF as fluorine source is described. The reaction is highly selective for alkyl iodides, bromide
Synthesis of fluorinated allylic amines: Reaction of 2-(trimethylsilyl)ethyl sulfones and sulfoxides with fluorinated imines
Fustero, Santos,Flores, Sonia,Cu?at, Ana C.,Jiménez, Diego,del Pozo, Carlos,Bueno, Jorge,Sanz-Cervera, Juan F.
, p. 1248 - 1254 (2008/02/08)
A new synthesis of fluorinated allylamines through the reaction of 2-(trimethylsilyl)ethyl sulfones and sulfoxides (as vinyl anion equivalents) with imines and imino esters has been described. The process includes a TBAF-mediated fragmentation of 2-(trime
Palladium-catalyzed tert-butoxycarbonylation of trifluoroacetimidoyl iodides
Amii, Hideki,Kishikawa, Yosuke,Kageyama, Katsuhiko,Uneyama, Kenji
, p. 3404 - 3408 (2007/10/03)
A modification and details of the palladium-catalyzed tert-butoxycarbonylation of 2,2,2-trifluoroacetimidoyl iodides 1, which gave the iminocarboxylates 2, one of the promising precursors to fluorinated α-amino acids, are described. The Pd-catalyzed carbonylation reaction was remarkably promoted by the use of DMF or DMI as an additive, enough to achieve the selective formation of tert-butyl iminoesters. Nucleophilic alkylation of the imine moiety of 2 and subsequent removal of N- and O-protecting groups gave a variety of 2-substituted 2-amino-3,3,3-trifluoropropanoic acid derivatives 3 in high yields.
A new approach to polyfluoroalkyl imidoyl iodide
Yu, Hong-Bin,Huang, Wei-Yuan
, p. 7999 - 8000 (2007/10/03)
Polyfluoroalkyl imidoyl iodide were prepared by reaction of polyfluoroalkyl iodide with N-arylisocyanide in the presence of sulfinatodehalogenation reagent (Na2S2O4/Na2CO3).
Generation and Reactions of Trifluoroacetimidoyl Radicals
Dan-oh, Yasufumi,Matta, Hirokazu,Uemura, Junko,Watanabe, Hisayuki,Uneyama, Kenji
, p. 1497 - 1508 (2007/10/02)
N-Aryltrifluoroacetimidoyl radicals have been generated by three different methods: the tin-radical promoted deiodination and photochemical homolysis of imidoyl iodides and the thermal homolysis of imidoyl azo-compounds.N-trifluoroace
One-Pot Synthesis of Trifluoroacetimidoyl Halides
Tamura, Kenji,Mizukami, Hiromichi,Maeda, Kazuhiro,Watanabe, Hisayuki,Uneyama, Kenji
, p. 32 - 35 (2007/10/02)
Trifluoroacetimidoyl chlorides 1 were obtained in 80-90percent yields when a mixture of trifluoroacetic acid and a primary amine was heated in carbon tetrachloride in the presence of triphenylphosphine and triethylamine.The corresponding bromides 2 were o
Homologation of trifluoroacetimidoyl iodides by palladium-catalyzed carbonylation. An approach to α-amino perfluoroalkanoic acids
Watanabe,Hashizume,Uneyama
, p. 4333 - 4336 (2007/10/02)
Homologation of trifluoroacetimidoyl iodides and the related perfluoro-compounds by palladium-catalyst under CO(1atm)-atmosphere in the presence of alcohols gives α-imino perfluoroalkanoates which are transformed to α-amino perfluoroalkanoic acids.
Palladium-catalyzed coupling reactions of trifluoroacetimidoyl iodides with olefins and 1-alkynes
Uneyama,Watanabe
, p. 1459 - 1462 (2007/10/02)
Palladium-catalyzed coupling of trifluoroacetimidoyl iodides with olefins and 1-alkynes affords trifluoromethylated α-β-unsaturated imines, which are transformed into nitrogen heterocycles bearing CF3-group.
