134481-27-9

Basic information

• Product Name: Ethanimidoyl iodide, 2,2,2-trifluoro-N-(4-methoxyphenyl)-
• CAS NO: 134481-27-9
• Molecular Formula: C9H7F3INO
• Molecular Weight: 329.06
• Mol File: 134481-27-9.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Ethanimidoyl iodide, 2,2,2-trifluoro-N-(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanimidoyl iodide, 2,2,2-trifluoro-N-(4-methoxyphenyl)-(134481-27-9)
• EPA Substance Registry System: Ethanimidoyl iodide, 2,2,2-trifluoro-N-(4-methoxyphenyl)-(134481-27-9)

Safety Data

• Hazardous Substances Data: 134481-27-9(Hazardous Substances Data)

Upstream product

• 75999-66-5 (Z)-2,2,2-trifluoro-N-(4-methoxyphenyl)acetimidoyl chloride 
• 104-94-9 4-methoxy-aniline 
• 2314-97-8 iodotrifluoromethane 
• 10349-38-9 p-methoxyphenylisonitrile 
• 75999-66-5 N-(4-methoxyphenyl)trifluoroacetimidoyl chloride 

Downstream Products

• 144008-26-4 3,3,3-Trifluoro-2-[(E)-4-methoxy-phenylimino]-propionic acid benzyl ester 
• 204130-91-6 4-methoxy-N-(1,1,1-trifluoro-4-phenylbut-3-yn-2-ylidene)aniline 
• 104-94-9 4-methoxy-aniline 
• 1111327-69-5 C₁₇H₁₆F₃NO 
• 1111327-67-3 C₁₇H₂₀F₃NO 
• 1111327-43-5 C₁₈H₁₄F₃NO₂ 
• 1111327-66-2 C₁₈H₁₄F₃NO 
• 1174217-43-6 CH₃SC₆H₄CCC(CF₃)NC₆H₄OCH₃ 
• 1352411-00-7 trans-Pd(η1-C(CF3)N(p-methoxyphenyl))(triphenylphosphine)2 
• 1352411-03-0 [Pd(η1-C(CF3)N(p-methoxyphenyl))(triphenylphosphine)2]4 

Relevant articles and documents

Selective formal transesterification of fluorinated 2-(trimethylsilyl)ethyl α-imino esters mediated by TBAF

(Chemical Equation Presented) The scope of the transesterification reaction between β-fluorinated α-imino esters and various electrophiles in the presence of TBAF as fluorine source is described. The reaction is highly selective for alkyl iodides, bromide

Palladium-catalyzed tert-butoxycarbonylation of trifluoroacetimidoyl iodides

A modification and details of the palladium-catalyzed tert-butoxycarbonylation of 2,2,2-trifluoroacetimidoyl iodides 1, which gave the iminocarboxylates 2, one of the promising precursors to fluorinated α-amino acids, are described. The Pd-catalyzed carbonylation reaction was remarkably promoted by the use of DMF or DMI as an additive, enough to achieve the selective formation of tert-butyl iminoesters. Nucleophilic alkylation of the imine moiety of 2 and subsequent removal of N- and O-protecting groups gave a variety of 2-substituted 2-amino-3,3,3-trifluoropropanoic acid derivatives 3 in high yields.

Generation and Reactions of Trifluoroacetimidoyl Radicals

N-Aryltrifluoroacetimidoyl radicals have been generated by three different methods: the tin-radical promoted deiodination and photochemical homolysis of imidoyl iodides and the thermal homolysis of imidoyl azo-compounds.N-trifluoroace