134482-51-2

Upstream product

• 68786-47-0 (Z)-2-(trityloxyimino)-2-(2-tritylamino-4-thiazolyl)acetic acid 
• 128438-01-7 (Z)-2-(2-aminothiazol-4-yl)-2-(triphenylmethoxyimino)acetic acid 
• 76-83-5 trityl chloride 

Downstream Products

• 220779-81-7 (6R,7R)-3-[(Z)-2-(3-Methoxy-isoxazol-5-yl)-vinyl]-8-oxo-7-{2-[2-(trityl-amino)-thiazol-4-yl]-2-[(Z)-trityloxyimino]-acetylamino}-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester 
• 220779-91-9 (6R,7R)-3-[(Z)-2-(3-Chloro-isoxazol-5-yl)-vinyl]-8-oxo-7-{2-[2-(trityl-amino)-thiazol-4-yl]-2-[(Z)-trityloxyimino]-acetylamino}-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester 
• 133731-33-6 4-methoxyphenylmethyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido>-3-<(Z)-3-carbamoyloxy-1-propenyl>-3-cephem-4-carboxylate 
• 133731-63-2 (6R,7R)-3-[(Z)-3-(Morpholine-4-carbonyloxy)-propenyl]-8-oxo-7-{2-[2-(trityl-amino)-thiazol-4-yl]-2-[(Z)-trityloxyimino]-acetylamino}-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester 
• 133731-55-2 4-methoxyphenylmethyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido>-3-<(Z)-3-(N-allylcarbamoyloxy)-1-propenyl>-3-cephem-4-carboxylate 
• 160786-22-1 (6R,7R)-8-Oxo-3-[(Z)-3-(pyrrolidine-1-carbonyloxy)-propenyl]-7-{2-[2-(trityl-amino)-thiazol-4-yl]-2-[(Z)-trityloxyimino]-acetylamino}-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester 
• 133731-49-4 4-methoxyphenylmethyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido>-3-<(Z)-3-tert-butyldimethylsilyloxy-1-propenyl>-3-cephem-4-carboxylate 
• 133731-53-0 4-methoxyphenylmethyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido>-3-<(Z)-3-(N-isopropylcarbamoyloxy)-1-propenyl>-3-cephem-4-carboxylate 
• 133754-57-1 4-methoxyphenylmethyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido>-3-<(Z)-3-(N,N-dimethylcarbamoyloxy)-1-propenyl>-3-cephem-4-carboxylate 
• 133731-54-1 4-methoxyphenylmethyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido>-3-<(Z)-3-(N-ethylcarbamoyloxy)-1-propenyl>-3-cephem-4-carboxylate 
• 133731-36-9 4-methoxyphenylmethyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido>-3-<(Z)-3-(N-methylcarbamoyloxy)-1-propenyl>-3-cephem-4-carboxylate 
• 133731-50-7 4-methoxyphenylmethyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido>-3-<(Z)-3-hydroxy-1-propenyl>-3-cephem-4-carboxylate 
• 220779-47-5 (6R,7R)-3-((Z)-2-Isoxazol-5-yl-vinyl)-8-oxo-7-{2-[2-(trityl-amino)-thiazol-4-yl]-2-[(Z)-trityloxyimino]-acetylamino}-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester 
• 162704-75-8 4-methoxyphenylmethyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido>-3-iodomethyl-3-cephem-4-carboxylate 

Relevant academic research and scientific papers

Structural modifications and biological evaluation of 3-isoxazolylvinylcephalosporins

Structural modifications and biological evaluations of 3-isoxazolylvinylcephalosporins (I) were performed. The replacement of a hydrogen atom at the 7-aminothiazole group by a chlorine resulted in an improvement of the activity against resistant Gram-posi

Studies in orally active cephalosporins. II. Synthesis and structure-activity relations of new [(E) or (Z) 3-substituted carbamoyloxy]-1-propenyl cephalosporins

In an effort to find a new oral cephalosporin with well-balanced antibacterial spectrum, good oral absorbability and long plasma half-life, a series of oxyimino aminothiazolyl 3-[(E)- or (Z)-N-substituted carbamoyloxy]propenyl cephems was synthesized and