1345014-44-9

Upstream product

• 1345013-92-4 tert-butyl 3-[bis(methylthio)methylene]-2,4-dioxopiperidine-1-carboxylate 
• 1345013-95-7 tert-butyl 4-(methylthio)-5-oxo-2-phenyl-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate 
• 1345014-05-2 tert-butyl 4-(methylsulfonyl)-5-oxo-2-phenyl-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate 
• 1345014-45-0 C₂₉H₃₈N₄O₅ 
• 98-86-2 acetophenone 

Relevant academic research and scientific papers

A modular synthesis of novel 4-amino-7,8-dihydro-1,6-naphthyridin-5(6H)- ones as PDE4 inhibitors

A versatile, modular synthetic route to a series of 4-amino-7,8-dihydro-1, 6-naphthyridin-5(6H)-ones has been developed. These compounds represent a novel structural class of potent phosphodiesterase IV (PDE4) inhibitors.

New 7,8-dihydro-1,6-naphthyridin-5(6h)-one-derivatives as PDE4 inhibitors

New 7,8-dihydro-1,6-naphthyridin-5(6H)-one derivatives derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of the phosphodiesterase IV (PDE4).