1345019-40-0

Upstream product

• 114105-64-5 (S)-(+)-2-(3,4-dimethoxyphenyl)-N-(1-phenylethyl)acetamide 
• 114105-51-0 (S)-(-)-[2-(3,4-dimethoxyphenyl)ethyl](1-phenylethyl)amine 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 
• 773837-37-9 sodium cyanide 
• 1345019-39-7 (S)-(+)-6,7-dimethoxy-2-(1-phenylethyl)-1,2,3,4-tetrahydroisoquinoline 

Downstream Products

• 1345019-42-2 (1S)-(-)-6,7-dimethoxy-2-[(1S)-1-phenylethyl]-1-[3-(tetrahydro-2H-pyran-2-yloxy)propyl]-1,2,3,4-tetrahydroisoquinoline 
• 1345019-47-7 (1S)-(-)-1-(2-(1,3-dioxolan-2-yl)ethyl)-6,7-dimethoxy-2-[(1S)-1-phenylethyl]-1,2,3,4-tetrahydroisoquinoline 

Relevant academic research and scientific papers

Synthesis of Tetrahydroisoquinoline Alkaloids and Related Compounds through the Alkylation of Anodically Prepared α-Amino Nitriles

α-Amino nitrile 2a was conveniently prepared in two individual steps from chiral hexafluorophosphate salt isoquinolinium (-)-8b including anodic cyanation as an efficient means to activate the sp3 C1-H bond of the THIQ nucleus. The lithiation o

Electrochemical synthesis and chemistry of chiral 1- cyanotetrahydroisoquinolines. An approach to the asymmetric syntheses of the alkaloid (-)-crispine A and its natural (+)-antipode

The stereoselective convergent total syntheses of both enantiomers of the tetrahydroisoquinoline (THIQ) alkaloid crispine A are described. The THIQ precursors ( - )-6 (90:10 dr) and ( - )-11 (85:15 dr) were prepared from the alkylation - reduction sequenc