134511-23-2

Usage

Uses

Used in Organic Synthesis:
(1R)-1-Cyclopropyl-1,2-ethanediol is used as a building block in organic synthesis for the preparation of various molecules. Its cyclopropyl ring and hydroxyl groups provide a versatile platform for the creation of complex organic compounds.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (1R)-1-Cyclopropyl-1,2-ethanediol is utilized as a key component in the development of pharmaceuticals. Its unique structural features allow it to be incorporated into the design of biologically active molecules, potentially leading to new treatments and therapies.
Used in Drug Development:
(1R)-1-Cyclopropyl-1,2-ethanediol holds promise in the development of new drugs due to its distinctive molecular structure. It may contribute to the creation of innovative pharmaceutical agents that address unmet medical needs.
Used in Material Science:
Although further research is required, (1R)-1-Cyclopropyl-1,2-ethanediol may also find applications in material science. Its cyclopropyl ring and hydroxyl groups could be exploited to engineer new materials with specific properties for various industrial applications.

Upstream product

• 693-86-7 ethenylcyclopropane 
• 188896-08-4 2-(benzyloxy)-1-cyclopropyl-1-ethanol 
• 1430108-13-6 2-[tert-butyl(dimethyl)silyl]oxy-1-cyclopropylethanol 
• 134624-47-8 (R)-cyclopropaneglycolic acid 
• 13885-13-7 2-cyclopropyl-2-oxoacetic acid 

Downstream Products

• 615251-46-2 toluene-4-sulfonic acid (S)-2-cyclopropyl-2-hydroxy-ethyl ester 
• 134511-24-3 (1R)-1-cyclopropyl-1-hydroxy-2-(4'-toluenesulfonyloxy)ethane 

Relevant academic research and scientific papers

N-substituted imidazole carboxylate compound, preparation method and medical uses thereof

The present invention relates to a compound represented by a general formula (I) or a stereoisomer, a solvate, a pharmaceutically acceptable salt or a eutectic, a composition, a preparation method and medical uses thereof, wherein the general formula (I) is defined in the specification, and each substituent is defined in the specification.

PREPARATION OF 24 ALKYL ANALOGS OF CHOLECALCIFEROL AND NON-RACEMIC COMPOUNDS

Disclosed is a process for the preparation of 24 -alkyl analogs of cholecalcyferol of Formula 1 having a (5E) or (5Z) configuration, wherein X represents a hydrogen atom, a hydroxy group or an OR1 group, wherein R1, R2

SYNTHESIS OF SOME 2'-C-ALKYL DERIVATIVES OF 9-(2-PHOSPHONOMETHOXYETHYL)ADENINE AND RELATED COMPOUNDS

To study the effect of β-substitution in 2'-alkyl derivatives of 9-(2-phosphonomethoxyethyl)adenine (Ia) on the antiviral activity or group specificity, these derivatives were synthesized. 9-(2-Hydroxyalkyl)adenines VIII were prepared by alkylation of adenine with suitably substituted oxiranes XIII or 2-hydroxyalkyl p-toluenesulfonates IV and VI.After protection of the adenine amino group by benzylation (compounds IX) or amidine formation (compounds X), the intermediates were alkylated with bis(2-propyl) p-toluenesulfonyloxymethanephosphonate (XI) in the presence of sodium hydride.After deprotection, the obtained phosphonate diesters XII were converted into phosphoniuc acids I by transsilylation and hydrolysis.This synthetic scheme was used for the preparation of ethyl (Ie), propyl (If), 2-propyl (Ig), 2-methylpropyl (Ih), cyclopropyl (Ii), cyclohexyl (Ij), benzyl (Ik) and phenyl (Il) derivatives.The 2'-trifluoromethyl derivative XXIIa was prepared analogously from 9-(2-hydroxy-3,3,3-trifluoropropyl)adenine (XXa), obtained by alkylation of adenine sodium salt with 2-hydroxy-3,3,3-trifluoropropyl bromide. 2,6-Diaminopurine derivative XXIIb was obtained analogously. 2'-Trimethylsilyl derivative XIXa was obtained by alkylation of adenine with 2-phosphonylmethoxy-3-(4-toluenesulfonyloxy)propyltrimethylsilane (XVII) followed by transsilylation and hydrolysis of diester XVIIIa. 9-(3-Phosphonomethoxybutyl)adenine (XXVIII) and 9-(2-methyl-2-phosphonomethoxypropyl)adenine (XXXV) were prepared from the corresponding hydroxy derivatives XXVIb and XXXII, respectively, by the same reaction pathway as derivatives I.

Synthesis of Optically Pure (R)-2-Hydroxy Acids using D-Lactate Dehydrogenase

Several (R)-2-hydroxy acids have been prepared in high optical purities and good yields using D-lactate dehydrogenase (Staphylococcus epidermidis) as the catalyst.