134511-23-2

Basic information

• Product Name: (1R)-1-Cyclopropyl-1,2-ethanediol
• Synonyms: (1R)-1-Cyclopropyl-1,2-ethanediol;1,2-Ethanediol, 1-cyclopropyl-, (1R)-
• CAS NO: 134511-23-2
• Molecular Formula: C₅H₁₀O₂
• Molecular Weight: 102.13
• Product Categories: Diols;Chiral Compounds
• Mol File: 134511-23-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (1R)-1-Cyclopropyl-1,2-ethanediol(CAS DataBase Reference)
• NIST Chemistry Reference: (1R)-1-Cyclopropyl-1,2-ethanediol(134511-23-2)
• EPA Substance Registry System: (1R)-1-Cyclopropyl-1,2-ethanediol(134511-23-2)

Safety Data

• Hazardous Substances Data: 134511-23-2(Hazardous Substances Data)

Usage

General Description

(1R)-1-Cyclopropyl-1,2-ethanediol is a chemical compound with the molecular formula C5H10O2. It is a cyclopropyl-containing diol, which means it has a cyclopropyl ring and two hydroxyl groups attached to the carbon atoms. (1R)-1-Cyclopropyl-1,2-ethanediol is used in organic synthesis and medicinal chemistry as a building block for the preparation of various pharmaceutical and biologically active molecules. It may also have potential applications in the development of new drugs and materials due to its unique structural features. However, further research and study are needed to fully understand the properties and potential uses of (1R)-1-Cyclopropyl-1,2-ethanediol.

Upstream product

• 1430108-13-6 2-[tert-butyl(dimethyl)silyl]oxy-1-cyclopropylethanol 
• 693-86-7 ethenylcyclopropane 
• 13885-13-7 2-cyclopropyl-2-oxoacetic acid 
• 134624-47-8 (R)-cyclopropaneglycolic acid 
• 188896-08-4 2-(benzyloxy)-1-cyclopropyl-1-ethanol 

Downstream Products

• 615251-46-2 toluene-4-sulfonic acid (S)-2-cyclopropyl-2-hydroxy-ethyl ester 
• 134511-24-3 (1R)-1-cyclopropyl-1-hydroxy-2-(4'-toluenesulfonyloxy)ethane 

Relevant articles and documents

N-substituted imidazole carboxylate compound, preparation method and medical uses thereof

The present invention relates to a compound represented by a general formula (I) or a stereoisomer, a solvate, a pharmaceutically acceptable salt or a eutectic, a composition, a preparation method and medical uses thereof, wherein the general formula (I) is defined in the specification, and each substituent is defined in the specification.

SYNTHESIS OF SOME 2'-C-ALKYL DERIVATIVES OF 9-(2-PHOSPHONOMETHOXYETHYL)ADENINE AND RELATED COMPOUNDS

To study the effect of β-substitution in 2'-alkyl derivatives of 9-(2-phosphonomethoxyethyl)adenine (Ia) on the antiviral activity or group specificity, these derivatives were synthesized. 9-(2-Hydroxyalkyl)adenines VIII were prepared by alkylation of adenine with suitably substituted oxiranes XIII or 2-hydroxyalkyl p-toluenesulfonates IV and VI.After protection of the adenine amino group by benzylation (compounds IX) or amidine formation (compounds X), the intermediates were alkylated with bis(2-propyl) p-toluenesulfonyloxymethanephosphonate (XI) in the presence of sodium hydride.After deprotection, the obtained phosphonate diesters XII were converted into phosphoniuc acids I by transsilylation and hydrolysis.This synthetic scheme was used for the preparation of ethyl (Ie), propyl (If), 2-propyl (Ig), 2-methylpropyl (Ih), cyclopropyl (Ii), cyclohexyl (Ij), benzyl (Ik) and phenyl (Il) derivatives.The 2'-trifluoromethyl derivative XXIIa was prepared analogously from 9-(2-hydroxy-3,3,3-trifluoropropyl)adenine (XXa), obtained by alkylation of adenine sodium salt with 2-hydroxy-3,3,3-trifluoropropyl bromide. 2,6-Diaminopurine derivative XXIIb was obtained analogously. 2'-Trimethylsilyl derivative XIXa was obtained by alkylation of adenine with 2-phosphonylmethoxy-3-(4-toluenesulfonyloxy)propyltrimethylsilane (XVII) followed by transsilylation and hydrolysis of diester XVIIIa. 9-(3-Phosphonomethoxybutyl)adenine (XXVIII) and 9-(2-methyl-2-phosphonomethoxypropyl)adenine (XXXV) were prepared from the corresponding hydroxy derivatives XXVIb and XXXII, respectively, by the same reaction pathway as derivatives I.