134518-11-9

Upstream product

• 57-14-7 N,N-Dimethylhydrazine 
• 134-81-6 benzil 

Downstream Products

• 50609-88-6 4,5-diphenyl-1-methyl-1H-imidazole 
• 129853-99-2 3-Methyl-5,6-diphenyl-3,6-dihydro-2H-1,3,4-thiadiazine 
• 125331-36-4 (3S,4R)-4-Benzoyl-1-dimethylamino-3-phenoxy-4-phenyl-azetidin-2-one 
• 125331-35-3 (3R,4R)-4-Benzoyl-1-dimethylamino-3-phenoxy-4-phenyl-azetidin-2-one 

Relevant academic research and scientific papers

Diastereoselective synthesis of 3,6-dihydro-2H-1,3,4- thiadiazines

Thionation of the benzil hydrazones 3 with Lawesson's reagent afforded the 3,6-dihydxo-2H-1,3,4-thiadiazines 4 by an intramolecular cyclisation. This reaction was shown to be diastereospecific and allowed the formation of the exo compounds 4b-e. When the homochiral SAMP-hydrazone 3f was used, the reaction afforded enantiomerically pure (4R,6R,9S)-4f.

Synthesis of β-lactams via cycloaddition of hydrazones with phenoxyketene

Phenoxyketene is capable of annelating the disubstituted hydrazones to afford stereoselectivity cis-monocyclic β-lactams with a 1-amino functionality. The ease of cycloaddition is governed by substitutents on the azomethine carbon as well as on the hydraz