13452-16-9

Basic information

• Product Name: 5-Chloro-2-Methyl-6-Nitrobenzoxazole
• Synonyms: 5-Chloro-2-Methyl-6-Nitrobenzoxazole;2-methyl-5-chloro-6-nitrobenzoxazole
• CAS NO: 13452-16-9
• Molecular Formula: C₈H₅ClN₂O₃
• Molecular Weight: 212.5899
• Mol File: 13452-16-9.mol

Chemical Properties

• Melting Point: 138 °C
• Boiling Point: 337.6±22.0 °C(Predicted)
• Appearance: /
• Density: 1.522±0.06 g/cm3(Predicted)
• PKA: -3.48±0.30(Predicted)
• CAS DataBase Reference: 5-Chloro-2-Methyl-6-Nitrobenzoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloro-2-Methyl-6-Nitrobenzoxazole(13452-16-9)
• EPA Substance Registry System: 5-Chloro-2-Methyl-6-Nitrobenzoxazole(13452-16-9)

Safety Data

• Hazardous Substances Data: 13452-16-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-Chloro-2-Methyl-6-Nitrobenzoxazole is used as a building block for the synthesis of pharmaceutical compounds due to its versatile properties and potential therapeutic applications.
Used in Cognitive Disorders Treatment:
5-Chloro-2-Methyl-6-Nitrobenzoxazole is used as a selective muscarinic M1 receptor agonist for the potential treatment of cognitive disorders such as Alzheimer's disease.
Used in Material Science:
5-Chloro-2-Methyl-6-Nitrobenzoxazole is used in the development of photochromic materials, which exhibit reversible changes in color upon exposure to light, making it of interest in the field of material science.

Upstream product

• 19219-99-9 2-methyl-5-chlorobenzoxazole 
• 13243-31-7 4-azido-2-chloro-1-nitrobenzene 
• 64-19-7 acetic acid 
• 53088-04-3 4-chloro-2-ethylideneamino-5-nitro-phenol 

Downstream Products

• 6358-07-2 2-amino-4-chloro-5-nitrophenol 
• 323579-00-6 5-chloro-2-methyl-benzoxazol-6-ylamine 

Relevant articles and documents

Method for synthesizing 2-amino-4-chloro-5-nitrophenol in micro-channel reactor

The invention discloses a method for synthesizing 2-amino-4-chloro-5-nitrophenol. The 2-amino-4-chloro-5-nitrophenol is prepared from 5-chloro-2-methylbenzoxazole through a series reaction using a micro-channel reactor and a batch reactor. The 2-amino-4-c

Compounds and synthesis process

Disclosed is a process for preparing a 6-chloro-2,5-dicarbonamido phenol compounds comprising a step employing a 2-alkyl-6-aminobenzoxazole to form a 2-alkyl-6-amino-7-chlorobenzoxazole in which the 2-alkyl group is unbranched at the α carbon. It also pro

Photographic element, compound, and process

Disclosed is a photographic element comprising a light-sensitive silver halide emulsion layer having associated therewith a cyan “NB coupler” having the formula (I): wherein the term “NB coupler” represents a coupler of formula (I) that forms a dye for wh

Photographic element, compound, and process

Disclosed is a photographic element comprising a light-sensitive silver halide emulsion layer having associated therewith a "NB coupler" having the formula (I): wherein :the term "NB coupler" represents a coupler of formula (I) that forms a dye for which

Photographic element, compound, and process

Disclosed is a photographic element comprising a light-sensitive silver halide emulsion layer having associated therewith a cyan "NB coupler" having the formula (I): wherein :the term "NB coupler" represents a coupler of formula (I) that forms a dye for w

Photographic element, compound, and process

Disclosed is a photographic element comprising a light-sensitive silver halide emulsion layer having associated therewith a cyan coupler having the formula: wherein:V is a sulfone or sulfoxide containing group;Y is H or a coupling-off group;W2

Compounds and synthesis process

Disclosed is a process for preparing 2,5-dicarbonamido phenol compounds comprising a step employing a 2-alkyl-6-nitro-benzoxazole to form a 2-alkyl-6-amino-benzoxazole in which the 2-alkyl group is unbranched at the α carbon. It also provides intermediate compounds useful in the process. The process provides a simple and safe way to prepare 2,5-dicarbonamido phenol compounds in good yield.