134527-22-3

Upstream product

• 10209-10-6 diphenylmethyl (6R,7R)-3-methyl-7β-phenoxyacetamidoceph-3-em-4-carboxylate 
• 78-94-4 methyl vinyl ketone 
• 134930-74-8 diphenylmethyl (1S,6R,7R)-3-methyl-4-(3'-oxobutyl)-7β-phenoxyacetamidoceph-2-em-4-carboxylate 1-oxide 

Downstream Products

• 134931-68-3 (1S,6R,7R)-3-methyl-4-(3'-oxobutyl)-7β-phenoxyacetamidoceph-2-em-4-carboxylic acid 1-oxide 
• 134930-76-0 (1S,6R,7R)-3-methyl-4-(3'-oxobutyl)-7β-phenoxyacetamido-ceph-3-em 1-oxide 
• 121406-66-4 (6R,7R)-3-methyl-4-(3'-oxobutyl)-7β-phenoxyacetamidoceph-3-em 
• 134930-74-8 diphenylmethyl (1S,6R,7R)-3-methyl-4-(3'-oxobutyl)-7β-phenoxyacetamidoceph-2-em-4-carboxylate 1-oxide 

Relevant academic research and scientific papers

Chemistry of Cephems: C-4 Substitution and Sulphoxide De-oxygenation Reactions.

The anion derived from ceph-3-em esters adds readily to Michael acceptors to give C-4 disubstituted ceph-2-ems.Oxidation of a typical adduct, such as the 4-cyanoethyl-4-diphenylmethyl ester, followed by ester hydrolysis and decarboxylation, gives the 4-cyanoethylceph-3-em sulphoxide which is easily reduced to the sulphide.Furthermore, zinc-acetic acid in DMF (dimethylformamide) is found to be an effective, mild reagent for the de-oxygenation of ceph-2-em sulphoxides.