1345344-02-6

Basic information

• Product Name: (E)-cyclo[N-methyloxy-2-(phenylmethylene)glycylprolyl]
• CAS NO: 1345344-02-6
• Molecular Weight: 272.304
• Mol File: 1345344-02-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (E)-cyclo[N-methyloxy-2-(phenylmethylene)glycylprolyl](CAS DataBase Reference)
• NIST Chemistry Reference: (E)-cyclo[N-methyloxy-2-(phenylmethylene)glycylprolyl](1345344-02-6)
• EPA Substance Registry System: (E)-cyclo[N-methyloxy-2-(phenylmethylene)glycylprolyl](1345344-02-6)

Safety Data

• Hazardous Substances Data: 1345344-02-6(Hazardous Substances Data)

Upstream product

• 607-81-8 diethyl 2-benzylmalonate 
• 35031-41-5 2-methoxyimino-3-phenylpropionic acid 
• 6943-96-0 ethyl 2-(hydroxyimino)-3-phenylpropanoate 
• 1345343-86-3 N-(α-methyloxime-3-phenylpropionyl)proline 
• 851769-53-4 ethyl 2-methoxyimino-3-phenylpropionate 

Relevant articles and documents

Synthesis and activity evaluation of the cyclic dipeptides arylidene N-alkoxydiketopiperazines

A series of arylidene N-alkoxydiketopiperazines was designed and stereoselectively synthesized via oxime-ether formation and intramolecular acylation. Possible cyclization and acid-catalyzed rearrangement-fragmentation mechanisms were discussed. The crystal structure of the novel diketopiperazine further confirmed the rearrangement mechanism. Most compounds exhibited antitumor activity. Several compounds were more potent against caspase-3. Specifically, compounds 6e, 6g, and 6f inhibited caspase-3 at IC50values lying within the low micromolar range and demonstrated good selectivity. The binding modes of alkoxydiketopiperazines in the active center of caspase-3 were also discussed based on the molecular docking results.