134538-48-0Relevant academic research and scientific papers
Guanidine-containing compound as well as preparation method and application thereof
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Paragraph 0119-0122; 0129-0132, (2021/11/26)
The invention discloses a cyanoguanidine-containing compound as well as a preparation method and application thereof. The invention also discloses a composition containing the cyanoguanidine-structured compound (I) or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier. The invention also discloses application thereof in preparation of analgesic drugs. The compounds of the invention are useful in the treatment of various pain.
Catalytic asymmetric Tamura cycloadditions involving nitroalkenes
Manoni, Francesco,Farid, Umar,Trujillo, Cristina,Connon, Stephen J.
, p. 1463 - 1474 (2017/02/15)
The first examples of asymmetric Tamura cycloaddition reactions involving singly activated alkenes are reported. Homophthalic anhydride reacts with α-methyl nitrosytrenes in the presence of an alkaloid-based catalyst to generate fused bicyclic aromatic ketone products with three new stereocentres (which are susceptible to subsequent equilibration) in 12-99% ee. An unusual equilibration process which occurs in methanolic medium in the absence of a recognisable base via proton transfer at the α-carbon of an ester was investigated experimentally and computationally.
Enantioselective hydrogenation of α,β-disubstituted nitroalkenes
Li, Shengkun,Huang, Kexuan,Zhang, Xumu
supporting information, p. 8878 - 8881 (2014/08/05)
The first highly chemo- and enantioselective hydrogenation of α,β-disubstituted nitroalkenes was accomplished with rhodium/JosiPhos-J2 as a catalyst, with the yield and enantioselectivity of up to 95% and 94%, respectively. The α-chiral nitroalkanes will provide an entry to valuable chiral amphetamines which are otherwise not so easily accessed. This journal is the Partner Organisations 2014.
Palladium-catalyzed synthesis of substituted nitroolefins
Chang, Meng-Yang,Lin, Chung-Han,Tai, Hang-Yi
supporting information, p. 3194 - 3198 (2013/06/26)
A one-pot protocol toward several substituted nitroolefins 4 and 6 starting with substituted acetones 2 and 5 was described. A facile process was carried out for the triflation of substituted acetones 2 and 5 with triflic anhydride (Tf2O) under the basic condition (Cs2CO3) and then palladium-catalyzed cross-coupling of enol triflates 3 with NaNO 2 and BINAP in the presence of phase-transfer reagents (n-Bu 4NBr) under the refluxing 1,2-dimethoxyethane (DME) in acceptable yields.
Alkenes from alcohols by tandem hydrogen transfer and condensation
Hall, Michael I.,Pridmore, Simon J.,Williams, Jonathan M. J.
supporting information; experimental part, p. 1975 - 1978 (2009/08/07)
A ruthenium-catalysed oxidation of alcohols by hydrogen transfer has been coupled with organocatalysed condensations using pyrrolidine or piperidine, to give α,β-unsaturated esters and nitroalkenes. Reactions proceed with high (E)-selectivity and provide an efficient and straightforward route to α,β-unsaturated compounds.
An efficient synthesis of (E)-nitroalkenes catalyzed by recoverable diamino-functionalized mesostructured polymers
Yan, Shaoyu,Gao, Yuan,Xing, Rong,Shen, Yali,Liu, Yueming,Wu, Peng,Wu, Haihong
, p. 6294 - 6299 (2008/09/21)
A clean, efficient, and simple method has been developed for synthesis of (E)-nitroalkenes using FDU-ED as an efficient catalyst. The reactions proceeded with moderate to high yields (60-96%) under mild conditions. The catalyst FDU-ED is recyclable and can be reused more than seven times without significant loss of activity and selectivity.
Heteroarylisopropylamines as MAO inhibitors
Vallejos, Gabriel,Fierro, Angelica,Rezende, Marcos Caroli,Sepulveda-Boza, Silvia,Reyes-Parada, Miguel
, p. 4450 - 4457 (2007/10/03)
The in vitro monoamine oxidase inhibitory (MAOI) activities of 11 heteroarylisopropylamines vis-a-vis MAO-A and MAO-B were described and interpreted in terms of possible interactions with the enzyme active site. Molecular dynamics simulations allowed a comparison between the most active MAO-A inhibitor of the series, the 1-(2-benzofuryl)-2-aminopropane, and the specific, analogous MAO-A substrate serotonin.
SiO2 Catalyzed Henry Reaction: Microwave Assisted Preparation of 2-Nitroalkanols in Dry Media
Kumar, H. M. Sampath,Reddy, B. V. Subba,Yadav, J. S.
, p. 637 - 638 (2007/10/03)
Nitroalkanes undergo rapid addition to aromatic aldehydes (Henry reaction) on the surface of activated SiO2, when irradiated with microwave, to afford 2-nitroalkanols in moderate to high yields.
HENRY CONDENSATION UNDER HIGH PRESSURE. 2. EFFECT OF AROMATIC ALDEHYDE TYPE AND PRESSURE ON THE YIELD OF ω-NITROSTYRENES AND SECONDARY PROCESSES
Agafonov, N. E.,Sedishev, I. P.,Dudin, A. V.,Kutin, A. A.,Stashina, G. A.,Zhulin, V. M.
, p. 366 - 372 (2007/10/02)
Condensation of aromatic aldehydes (I)-(XX) with EtNO2 and n-PrNO2 in AcOH in the presence of AcONH4 or i-BuNH2 gives primarily ω-nitrostyrenes (Ia, b) - (XXa, b) and small quantities of nitriles (Ic) - (XXc), oximes (Id) - (XXd), and ketones (Ie, f) - (XXe, f).The yields of (Ia, b) - (XXa, b) at P = 1 atm are higher for acceptor substitutents on the aromatic ring whereas at P = 10 kbar, they are higher for donor substituents.High pressures suppress the formation of (Ic-f) - (XXc-f) and the Z-isomers of (Ia, b) - (XXa, b).The high pressure technique is especially useful in the preparation of donor-substituted (Ia, b) - (XXa, b) which are intermediates in the synthesis of the psychotropic β-phenylethylamines.
