1345470-29-2Relevant academic research and scientific papers
Palladium-catalyzed coupling of arene C-H bonds with methyl- and arylboron reagents assisted by the removable 2-pyridylsulfinyl group
Romero-Revilla, Jose A.,Garcia-Rubia, Alfonso,Gomez Arrayas, Ramon,Fernandez-Ibanez, M. Angeles,Carretero, Juan C.
experimental part, p. 9525 - 9530 (2012/01/06)
The PdII-catalyzed direct coupling of arene C-H bonds with organoboron reagents assisted by the 2-pyridylsulfinyl group is reported. Methylboronic acid and arylboronic acid neopentyl esters proved to be efficient coupling partners, furnishing methylated arenes and biaryl products in moderate to good yields. The 2-pyridylsulfinyl group can be easily removed to provide the free biaryls. The essential role of the 2-pyridyl unit in stabilizing the cyclopalladation complex was demonstrated by X-ray diffraction analysis of the palladacycle intermediate.
