1345501-37-2Relevant academic research and scientific papers
Enantioselective and regioselective Friedel-Crafts alkylation of pyrroles with nitroalkenes catalyzed by a tridentate Schiff base-copper complex
Guo, Fengfeng,Chang, Dalu,Lai, Guoyin,Zhu, Tao,Xiong, Shunshun,Wang, Sujing,Wang, Zhiyong
, p. 11127 - 11130 (2011)
On a (pyr)role: A mild and highly efficient catalytic system has been developed for the asymmetric Friedel-Crafts alkylation of pyrroles with nitroalkenes (see scheme). High yields, and excellent enantioselectivities and regioselectivities were obtained for a broad range of substrates. The synthetic utility of this methodology and mechanistic studies involving a novel, negative, nonlinear effect are also presented. Copyright
