1345509-59-2

Upstream product

• 637-81-0 ethyl-2-azidoacetate 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 

Downstream Products

• 1345509-64-9 ethyl 1,2-diphenyl-4-(3,4,5-trimethoxyphenyl)-1H-imidazole-5-carboxylate 
• 128781-07-7 5,6,7-trimethoxy-1H-indole-2-carboxylic acid 
• 351890-38-5 6-benzyloxy-3-chloromethyl-1,2-dihydro-1-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]indoline 
• 1421933-06-3 ethyl 5-amino-4-cyano-2-(3,4,5-trimethoxyphenyl)-1H-pyrrole-3-carboxylate 

Relevant academic research and scientific papers

Structural influence of indole C5-N-substitutents on the cytotoxicity of seco-duocarmycin analogs

A series of racemic indole C5-substituted seco-cyclopropylindoline compounds (2,3 and 5-7) were prepared by coupling 1-(tert-butyloxycarbonyl)-3- (chlorocarbonyl)indoline (seg-A) with 5,6,7-trimethoxy-, 5,6-dimethoxy-, 5-amino-, 5-methylsulfonylamino- and 5-(N,N-dimethylaminosulfonylamino) indole-2-carboxylic acid as seg-B in the presence of 1-ethyl-3-(3- dimethylaminopropyl) carbodiimide. The synthetic compounds (2,3 and 5-7) were tested for cytotoxic activity against human cancer cell lines (COLO 205, SK-MEL-2, A549, and JEG-3) using the MTT assay.