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1345515-22-1 Usage

General Description

1-(3-hydroxy-2-methylquinolin-4-yl)ethanone is a chemical compound belonging to the class of organic compounds known as quinolines and derivatives. Quinolines and their derivatives are compounds containing a ring fusion of a benzene and pyridine ring. The structure of 1-(3-hydroxy-2-methylquinolin-4-yl)ethanone is characterized by a 2-methylquinolin-4-yl group attached to an ethanone moiety at the 1-position, with a hydroxy group on the 3-position of the quinoline ring. 1-(3-hydroxy-2-methylquinolin-4-yl)ethanone is soluble in most organic solvents, and can be synthesized in laboratories. It does not have extensive applications, and is mostly used in scientific research.

Check Digit Verification of cas no

The CAS Registry Mumber 1345515-22-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,4,5,5,1 and 5 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1345515-22:
141 % 10 = 1
So 1345515-22-1 is a valid CAS Registry Number.



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017


1.1 GHS Product identifier

Product name 1-(3-hydroxy-2-methylquinolin-4-yl)ethanone

1.2 Other means of identification

Product number -
Other names 2-methyl-3-hydroxy-4-acetylquinoline

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1345515-22-1 SDS

1345515-22-1Downstream Products

1345515-22-1Relevant articles and documents

Discovery of MK-8831, A Novel Spiro-Proline Macrocycle as a Pan-Genotypic HCV-NS3/4a Protease Inhibitor

Neelamkavil, Santhosh F.,Agrawal, Sony,Bara, Thomas,Bennett, Chad,Bhat, Sathesh,Biswas, Dipshikha,Brockunier, Linda,Buist, Nicole,Burnette, Duane,Cartwright, Mark,Chackalamannil, Samuel,Chase, Robert,Chelliah, Mariappan,Chen, Austin,Clasby, Martin,Colandrea, Vincent J.,Davies, Ian W.,Eagen, Keith,Guo, Zhuyan,Han, Yongxin,Howe, John,Jayne, Charles,Josien, Hubert,Kargman, Stacia,Marcantonio, Karen,Miao, Shouwu,Miller, Randy,Nolting, Andrew,Pinto, Patrick,Rajagopalan, Murali,Ruck, Rebecca T.,Shah, Unmesh,Soriano, Aileen,Sperbeck, Donald,Velazquez, Francisco,Wu, Jin,Xia, Yan,Venkatraman, Srikanth

, p. 111 - 116 (2016/02/03)

We have been focused on identifying a structurally different next generation inhibitor to MK-5172 (our Ns3/4a protease inhibitor currently under regulatory review), which would achieve superior pangenotypic activity with acceptable safety and pharmacokinetic profile. These efforts have led to the discovery of a novel class of HCV NS3/4a protease inhibitors containing a unique spirocyclic-proline structural motif. The design strategy involved a molecular-modeling based approach, and the optimization efforts on the series to obtain pan-genotypic coverage with good exposures on oral dosing. One of the key elements in this effort was the spirocyclization of the P2 quinoline group, which rigidified and constrained the binding conformation to provide a novel core. A second focus of the team was also to improve the activity against genotype 3a and the key mutant variants of genotype 1b. The rational application of structural chemistry with molecular modeling guided the design and optimization of the structure-activity relationships have resulted in the identification of the clinical candidate MK-8831 with excellent pan-genotypic activity and safety profile.

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