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50488-44-3

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50488-44-3 Usage

Description

4-Bromo-2-methylquinoline is a chemical compound belonging to the quinoline family, characterized by the molecular formula C10H8BrN. It features a quinoline ring with a bromine atom and a methyl group attached, endowing it with unique structural and functional properties. 4-Bromo-2-methylquinoline is recognized for its potential biological activities and has been extensively studied for its antimicrobial, antifungal, and anticancer properties. Additionally, it serves as a valuable building block in organic synthesis and pharmaceutical research, as well as a reagent in various chemical reactions, making it a versatile component in both scientific research and industrial applications.

Uses

Used in Pharmaceutical Research:
4-Bromo-2-methylquinoline is used as a building block for the development of new pharmaceutical compounds due to its potential biological activities. Its unique structure allows for the creation of novel drugs with improved therapeutic properties.
Used in Organic Synthesis:
As a key intermediate in organic synthesis, 4-Bromo-2-methylquinoline is used to construct complex organic molecules. Its reactivity and structural features make it a valuable component in the synthesis of various organic compounds.
Used in Antimicrobial Applications:
4-Bromo-2-methylquinoline is used as an antimicrobial agent for its ability to inhibit the growth of certain microorganisms. Its potential applications include the development of new antibiotics and antifungal agents to combat drug-resistant infections.
Used in Anticancer Research:
4-Bromo-2-methylquinoline is used as a potential anticancer agent, with ongoing research exploring its effects on various types of cancer. Its unique structure and biological activities make it a promising candidate for the development of novel cancer therapies.
Used in Chemical Reactions:
4-Bromo-2-methylquinoline serves as a reagent in various chemical reactions, taking advantage of its unique structural features to facilitate specific transformations and syntheses. This versatility makes it a valuable tool in the field of chemistry.

Check Digit Verification of cas no

The CAS Registry Mumber 50488-44-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,0,4,8 and 8 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 50488-44:
(7*5)+(6*0)+(5*4)+(4*8)+(3*8)+(2*4)+(1*4)=123
123 % 10 = 3
So 50488-44-3 is a valid CAS Registry Number.
InChI:InChI=1/C10H8BrN/c1-7-6-9(11)8-4-2-3-5-10(8)12-7/h2-6H,1H3

50488-44-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Bromo-2-methylquinoline

1.2 Other means of identification

Product number -
Other names Quinoline,4-bromo-2-methyl

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:50488-44-3 SDS

50488-44-3Relevant articles and documents

CARBOXY SUBSTITUTED (HETERO) AROMATIC RING DERIVATIVES AND PREPARATION METHOD AND USES THEREOF

-

, (2017/03/21)

Carboxy-substituted (hetero)aryl derivatives, pharmaceutical compositions comprising these compounds, and methods of preparing such compounds and compositions are provided. The compounds or compositions are useful in inhibiting xanthine oxidase and urate anion transporter 1, and also can be used in the treatment or prevention of diseases associated with high blood uric acid level in mammals, especially humans.

Design, synthesis and biological evaluation of 2-substituted quinolines as potential antileishmanial agents

Gopinath, Vadiraj S.,Pinjari, Jakir,Dere, Ravindra T.,Verma, Aditya,Vishwakarma, Preeti,Shivahare, Rahul,Moger, Manjunath,Kumar Goud, Palusa Sanath,Ramanathan, Vikram,Bose, Prosenjit,Rao,Gupta, Suman,Puri, Sunil K.,Launay, Delphine,Martin, Denis

, p. 527 - 536 (2013/10/22)

An analogous library of 2-substituted quinoline compounds was synthesized with the aim to identify a potential drug candidate to treat visceral leishmaniasis. These molecules were tested for their in vitro and in vivo biological activity against Leishmania donovani. Metabolic stability of these compounds was also improved through the introduction of halogen substituents. Compound (26g), found to be the most active; exhibited an IC50 value of 0.2 μM and >180 fold selectivity. The hydrochloride salt of (26g) showed 84.26 ± 4.44 percent inhibition at 50 mg/kg × 5 days (twice daily, oral route) dose in L. donovani/hamster model. The efficacy was well correlated with the PK data observed which indicating that the compound is well distributed.

Hydantoins and related heterocycles as inhibitors of matrix metalloproteinases and/or TNF-alpha converting enzyme (TACE)

-

, (2008/06/13)

The present application describes novel hydantoin derivatives of formula (I): or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, R1, R2, R3, R4, R5, R6, R7, R11, and n are defined in the present specification, which are useful as inhibitors of matrix metalloproteinases (MMP), TNF-α converting enzyme (TACE), aggrecanase, or a combination thereof.

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