1345539-92-5Relevant articles and documents
New PDE4 inhibitors based on pharmacophoric similarity between papaverine and tofisopam
Bihel, Frédéric J.J.,Justiniano, Héléne,Schmitt, Martine,Hellal, Malik,Ibrahim, Mohamed A.,Lugnier, Claire,Bourguignon, Jean-Jacques
, p. 6567 - 6572 (2011/12/04)
Pharmacophoric comparison between papaverine and tofisopam led to identify three new series of microto sub-micromolar inhibitors of phosphodiesterase-4, including 7,8-dialkoxy-2,3-benzodiazepin-4-one derivatives, 7,8-dialkoxy-1,4- benzodiazepin-2-one derivatives, and dialkoxybenzophenone derivatives.