92157-09-0

Basic information

• Product Name: methyl 2-(3,4-diethoxyphenyl)acetate
• Synonyms: methyl 2-(3,4-diethoxyphenyl)acetate
• CAS NO: 92157-09-0
• Molecular Weight: 238.284
• Mol File: 92157-09-0.mol

Chemical Properties

• CAS DataBase Reference: methyl 2-(3,4-diethoxyphenyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(3,4-diethoxyphenyl)acetate(92157-09-0)
• EPA Substance Registry System: methyl 2-(3,4-diethoxyphenyl)acetate(92157-09-0)

Safety Data

• Hazardous Substances Data: 92157-09-0(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 38464-04-9 3,4-diethoxy-phenyl-acetic acid 
• 279262-08-7 3,4-diethoxyphenylboronic acid 
• 96-32-2 bromoacetic acid methyl ester 
• 17345-77-6 1-bromo-3,4-dihydroxybenzene 
• 53207-08-2 4-bromo-1,2-diethoxybenzene 

Downstream Products

• 38464-04-9 3,4-diethoxy-phenyl-acetic acid 
• 1345539-92-5 C₂₂H₂₂O₅S 
• 1345540-08-0 C₁₉H₂₀N₂O₃ 
• 474069-98-2 C₁₉H₁₉ClN₂O₃ 
• 1345540-12-6 C₁₉H₁₉ClN₂O₃ 
• 6298-46-0 N-(3,4-diethoxyphenylacetyl)-β-(3,4-diethoxyphenyl)ethylamine 
• 911-60-4 1-(3',4'-diethoxybenzyl)-6,7-diethoxy-3,4-dihydroisoquinoline hydrochloride 
• 61381-04-2 2-(3,4-diethoxyphenyl)ethylamine 

Relevant articles and documents

Novel preparation method of drotaverine hydrochloride intermediate

The invention discloses a novel preparation method of a drotaverine hydrochloride intermediate. The preparation method comprises the steps that 1, 4-bromopyrocatechol serves as the raw material and issubjected to an ethylation reaction under the action of iodoethane or diethyl sulfate, and 1,2-diethoxy-4-bromobenzene is prepared; 2, 1,2-diethoxy-4-bromobenzene is subjected to a Suzuki-Miyaura coupling reaction and reacts with ethyl bromoacetate or methyl bromoacetate to prepare 3,4-diethoxyphenylaceticacid ester; 3, 3,4-diethoxyphenylaceticacid is hydrolyzed to prepare 3,4-diethoxyphenylaceticacid; 4, 3,4-diethoxyphenylaceticacid ester and ammonia are prepared into 3,4-diethoxyphenylacetamide; 5, 3,4-diethoxyphenylacetamide is reduced to prepare 3,4-diethoxyphenethylamine. The direct preparation method is used; in the process of preparing 3,4-diethoxyphenyl acetonitrile, application of sodium cyanide is avoided; when 3,4-diethoxyphenethylamine is prepared, lithium aluminium hydride isused for reduction, and a pressurized hydrogenation method is prevented from being used, so that the problems about safety and environment pollution are effectively solved, the process is simple andeasy to implement, and the practicality is high.

New PDE4 inhibitors based on pharmacophoric similarity between papaverine and tofisopam

Pharmacophoric comparison between papaverine and tofisopam led to identify three new series of microto sub-micromolar inhibitors of phosphodiesterase-4, including 7,8-dialkoxy-2,3-benzodiazepin-4-one derivatives, 7,8-dialkoxy-1,4- benzodiazepin-2-one derivatives, and dialkoxybenzophenone derivatives.