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Usage

Uses

Used in Pharmaceutical Research:
(R)-Benzyl 2-(pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate is used as a building block in the synthesis of larger pharmacological compounds for [application reason]. Its nitrogen-containing structure and carboxylate groups make it a versatile component in the development of new drugs.
Used in Chemical Research:
(R)-Benzyl 2-(pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate is used as a research compound in various chemical studies for [application reason]. Its complex structure and specific spatial arrangement provide valuable insights into the properties and behavior of similar compounds in chemical reactions and processes.
Used in Organic Chemistry:
(R)-Benzyl 2-(pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate is used as a reagent or intermediate in the synthesis of organic compounds for [application reason]. Its benzyl group and carboxylate groups facilitate various chemical reactions, making it a useful component in the preparation of a wide range of organic molecules.

InChI:InChI=1/C17H22N2O3/c20-16(18-10-4-5-11-18)15-9-6-12-19(15)17(21)22-13-14-7-2-1-3-8-14/h1-3,7-8,15H,4-6,9-13H2

Upstream product

• 1148-11-4 Z-D-proline 
• 109-97-7 pyrrole 
• 6404-31-5 Z-D-proline 
• 123-75-1 pyrrolidine 

Relevant academic research and scientific papers

AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS

Aminopyridine and aminopyrazine compounds of formula (1), compositions including these compounds, and methods of their use are provided. Preferred compounds of formula 1 have activity as protein kinase inhibitors, including as inhibitors of c-MET.

5-ARALKYSUFONYL-3-(PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AS KINASE INHIBITORS

The present invention relates to certain 5-aralkylsulfonyl-3-(pyrrol-2-yl-methylidene)-2-indolinone derivatives that inhibit kinases, in particular met kinase. Pharmaceutical compositions comprising these compounds, methods of treating diseases mediated by kinases utilizing pharmaceutical compositions comprising these compounds, and methods of preparing them are also disclosed.

Structure activity relationship of inhibitors specific for prolyl endopeptidase.

Structural requirements of N-blocked L-proline derivatives as specific inhibitors for prolyl endopeptidase were investigated using a series of substrate analogs. Replacement of L-proline by its D-isomer remarkably reduced the inhibition. Introduction of a sulfur atom in proline and/or in the penultimate pyrrolidine rings significantly increased the inhibition, but the introduction of oxygen rather diminished the activity. A peptide linkage (acid-amide bond) between the proline and the pyrrolidine ring was also required to keep the inhibitory activity. A benzyloxycarbonyl group was most effective as an N-blocked component of the inhibitors.